3 ms·

No comments on saturated fat vs liver disease (ie fatty liver) though. The common wisdom, I believe, is that you want to avoid sat-fat if you have fatty liver d

No comments on saturated fat vs liver disease (ie fatty liver) though. The common wisdom, I believe, is that you want to avoid sat-fat if you have fatty liver disease. That may not be a killer like cvd, but it is a big deal too.

deleted 4y ago
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joecool1029 4y ago
A lot of people in here pointing to fructose though as a primary driver of problems, not saturated fat. Unlike glucose which can be used almost everywhere in the body, excess fructose has to be processed in the liver. In a caloric excess (which can be further exasperated by consumption of additional saturated fat), it's going to be converted to fat in the liver. More on that topic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838515/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838515/
- oneepic 4y ago
  Thanks for the article, looks like that one is from 2016. I'll share another article I found with a quick search -- "Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars" : https://pubmed.ncbi.nlm.nih.gov/29844096/ https://pubmed.ncbi.nlm.nih.gov/29844096/ Now I'm not so sure which is the "primary driver". There are quite a few competing thoughts but maybe the point is you should lower both. That's probably one reason many docs (including mine in the past) recommend cutting both.
  - joecool1029 4y ago
    > Now I'm not so sure which is the "primary driver". There are quite a few competing thoughts but maybe the point is you should lower both. On that I don't think we disagree. However, saturated fat on its own isn't super palatable. There was a community I discovered a few years ago deliberately trying to up their saturated fat intake (specifically steric acid) and on it's own it's about as pleasurable as chewing on a candlestick (steric acid is used as a stiffener in paraffin candles). One thing I remember seeing too is that inflammation increases damage caused by de novo lipogenesis. I am wondering if consumption of stable saturated fats vs. consumption of unstable (and commonly rancid polyunsaturated fats) exasperates things.

deleted 4y ago

[deleted]

joecool1029 4y ago

A lot of people in here pointing to fructose though as a primary driver of problems, not saturated fat. Unlike glucose which can be used almost everywhere in the body, excess fructose has to be processed in the liver. In a caloric excess (which can be further exasperated by consumption of additional saturated fat), it's going to be converted to fat in the liver. More on that topic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838515/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838515/

oneepic 4y ago
Thanks for the article, looks like that one is from 2016. I'll share another article I found with a quick search -- "Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars" : https://pubmed.ncbi.nlm.nih.gov/29844096/ https://pubmed.ncbi.nlm.nih.gov/29844096/ Now I'm not so sure which is the "primary driver". There are quite a few competing thoughts but maybe the point is you should lower both. That's probably one reason many docs (including mine in the past) recommend cutting both.
- joecool1029 4y ago
  > Now I'm not so sure which is the "primary driver". There are quite a few competing thoughts but maybe the point is you should lower both. On that I don't think we disagree. However, saturated fat on its own isn't super palatable. There was a community I discovered a few years ago deliberately trying to up their saturated fat intake (specifically steric acid) and on it's own it's about as pleasurable as chewing on a candlestick (steric acid is used as a stiffener in paraffin candles). One thing I remember seeing too is that inflammation increases damage caused by de novo lipogenesis. I am wondering if consumption of stable saturated fats vs. consumption of unstable (and commonly rancid polyunsaturated fats) exasperates things.