It's also worth mentioning that Jamie Zawinski, cited in the article, burned out and quit the industry. If your startup is really changing the world, fine. But

It's also worth mentioning that Jamie Zawinski, cited in the article, burned out and quit the industry. If your startup is really changing the world, fine. But is working on <generic web-app> worth sacrificing your love for programming itself (not to mention the health effects and opportunity costs involved)?