6 ms·

Over a million people, in the U.S. alone, died in under two years after being infected with this virus. Even granting the unlikely possibility that this mouse

Over a million people, in the U.S. alone, died in under two years after being infected with this virus. Even granting the unlikely possibility that this mouse model is reflective of the immune response in humans, whatever other microorganisms people were encountering were demonstrably less dangerous than SARS-CoV-2. Unless you know of some other highly infectious microorganism that rapidly spread to hundreds of millions of people and killed 1-2% of those it infected?

taolegal 4y ago
> Even granting the genuinely unlikely possibility that this mouse model is reflective of the immune response in humans, whatever other microorganisms people were encountering were demonstrably less dangerous than SARS-CoV-2. The mouse model is apparently enough for the new booster.
- peter422 4y ago
  So they ran the phase 2/3 trial in >1000 humans for fun? The problem with anti-vaxxers is you just imagine a world in which everything is underhanded and a conspiracy when all the science and data is out there in the open, just ignored.
  - taolegal 4y ago
    Anti-vax? You have no clue what my beliefs are on this, I'm not anti-vaccine. I remember just last year the Biden administration forced through the booster shots (after a propaganda campaign predicated one & done, that then extended into mandates, which Biden, Pelosi & others said were never on the table or illegal, later to be proven unconstitutional by the supreme court). Senior officials at the FDA resigned over the insufficient evidence of efficacy. Not only was it unclear that they should be approved for seniors, they just opened it up to everyone. It's only gotten worse now. It's not even remotely clear to me that the average healthy person (not on the standard American diet, chronically ill with the typical stuff like diabetes & obesity) needs upwards of 4 vaccines, and counting, for a virus that's much more attenuated & practically everyone has some form of immunity at this point. Also: to answer your question, from what I can tell the studies haven't shown efficacy. They only show that antibodies rose, which we know isn't absolute proof of efficacy with regards to infection or disease.
    - peter422 4y ago
      I never said the trials showed efficacy, though there are multiple high quality trials which do show serious benefits of 3rd/4th shots in various age groups. I just say they ran human trials, which your comment implied they didn’t. Also: - no good evidence the virus is attenuated (lower hospitalizations/mortality likely driven by increased population immunity) - a lot of FDA/CDC officials agreed with the decision too, and I think on the whole were proved right to offer to the booster to older populations before all the studies were completed. - nobody is forcing you to get the 3rd/4th shots, why do you want to prevent other people from getting them if they want them? You are sooo sure they are bad?
      - taolegal 4y ago
        Sure let people get them voluntarily. My point is that all this irrational exuberance is very clearly precipitously eroding trust in public health authority & science generally.
        peter422 4y ago
        You incorrectly said 3 posts ago that the new boosters were only tested in mouse models. You are actively attempting to erode trust in public health and then lamenting that people are losing trust in public health. Give me a break.
        taolegal 4y ago
        If you're going to unveil a new vaccine it should be proven to be effective. Anything else at this point (when practically everyone has developed an immune response through infection or previous vaccination) is unethical. The mouse models were challenge studies, i.e. how do vaccinated mice respond to exposure to the omicron variant? That's what matters. Versus what you are demagoguing. Conflating with "tested", that since the new booster was given to humans and no abnormal AEs were observed & antibody levels rose, that automatically means it must be effective. This is precisely the scenario that degrades public trust in institutions when this fast-and-loose science is being rolled-out live on large populations.
  - spookthesunset 4y ago
    It doesn’t require a conspiracy to think something is majorly wrong with how the last 2.5 years were handled. Everybody played to their incentives and thought they were doing the right thing. The outcome was a complete disaster and a horrific overreaction. But people thought they were doing the right thing. It’s kind of like a modern engineering failure. It takes multiple failures to bring down complex, redundant systems. That is what happened here. > when all the science and data is out there in the open, just ignored. I lost count of the number of times somebody yelled or called me “dangerous” for showing this data. Most of the public data goes directly against the narrative people like to push. It gets tossed right into the “conspiracy” bin. Virtually nothing about our response was based on science or data.
    - peter422 4y ago
      > Virtually nothing about our response was based on science or data. Virtually nothing? So the thousands and thousands of studies on vaccines, treatments, mask policies, vaccine policies, school policies, air filtration techniques, etc, etc… those were just done for no reason? To say we live in an imperfect society with imperfect leaders and imperfect citizens is a fair point. Incorrect decisions were and continue to be made for political reasons or religious reasons or whatever else. That’s what happens in an imperfect society. To say “virtually nothing” about the response is based on data is just ridiculous. Again, anti-vaxxers and conspiracy theorists make up a world where decisions are made in secret for suspicious reasons when generally all the data and arguments are out in the open and are just ignored.
      - spookthesunset 4y ago
        > anti-vaxxers and conspiracy theorists Are all the highly esteemed professors, scientists, politicians, healthcare workers, and researchers who signed the great barrington declaration anti-vaxx conspiracy theorists? Do you have any idea how many people in real life yelled at me and called me incredibly nasty things for suggesting that maybe, just maybe this myopic fixation on Covid was going to have some serious long term effects and maybe, just maybe we are overreacting? You can’t speak against the narrative. Speaking out against what we did was and still is career suicide if you are in healthcare, science or research. There has been a continual incredibly strong push to label anything that goes against “the narrative” as misinformation, “anti-whatever”. Speaking out as a member of the medical/science community gets you blacklisted. Beware of any research that got published in the heat of this mess—there were strong incentives to only publish research that supported “the narrative”.
  - omniglottal 4y ago
    Do not make such assumptions - it is against the guidelines and is abusive to the notion that we can engage in dialogue here in good faith.
omniglottal 4y ago
Why not plural microorganismS? Although a neglible increase of mortality across countless events where broad-acting immunity protects us may be outside your ability to calculate, it's still readily applicable to recognize that a lot of straw exists on a camel's back without simply studying just the one which broke it. An overall increase in mortality from all causes is congruent with valid scientific theory and is a hypothesis worth evaluating without eschewing existing data. Your question is unneccessarily leading with false premises by which you define the answer without accepting the known truth. If you're looking for just one organism which would need to spread, then you're looking in the wrong place for how, i.e., people were killed by myocarditis, or inability to stay nourished while suffering vaccine-induced side effects, including inability to defend with the same metabolic fervor from the flu.

taolegal 4y ago

> Even granting the genuinely unlikely possibility that this mouse model is reflective of the immune response in humans, whatever other microorganisms people were encountering were demonstrably less dangerous than SARS-CoV-2. The mouse model is apparently enough for the new booster.

peter422 4y ago
So they ran the phase 2/3 trial in >1000 humans for fun? The problem with anti-vaxxers is you just imagine a world in which everything is underhanded and a conspiracy when all the science and data is out there in the open, just ignored.
- taolegal 4y ago
  Anti-vax? You have no clue what my beliefs are on this, I'm not anti-vaccine. I remember just last year the Biden administration forced through the booster shots (after a propaganda campaign predicated one & done, that then extended into mandates, which Biden, Pelosi & others said were never on the table or illegal, later to be proven unconstitutional by the supreme court). Senior officials at the FDA resigned over the insufficient evidence of efficacy. Not only was it unclear that they should be approved for seniors, they just opened it up to everyone. It's only gotten worse now. It's not even remotely clear to me that the average healthy person (not on the standard American diet, chronically ill with the typical stuff like diabetes & obesity) needs upwards of 4 vaccines, and counting, for a virus that's much more attenuated & practically everyone has some form of immunity at this point. Also: to answer your question, from what I can tell the studies haven't shown efficacy. They only show that antibodies rose, which we know isn't absolute proof of efficacy with regards to infection or disease.
  - peter422 4y ago
    I never said the trials showed efficacy, though there are multiple high quality trials which do show serious benefits of 3rd/4th shots in various age groups. I just say they ran human trials, which your comment implied they didn’t. Also: - no good evidence the virus is attenuated (lower hospitalizations/mortality likely driven by increased population immunity) - a lot of FDA/CDC officials agreed with the decision too, and I think on the whole were proved right to offer to the booster to older populations before all the studies were completed. - nobody is forcing you to get the 3rd/4th shots, why do you want to prevent other people from getting them if they want them? You are sooo sure they are bad?
    - taolegal 4y ago
      Sure let people get them voluntarily. My point is that all this irrational exuberance is very clearly precipitously eroding trust in public health authority & science generally.
      - peter422 4y ago
        You incorrectly said 3 posts ago that the new boosters were only tested in mouse models. You are actively attempting to erode trust in public health and then lamenting that people are losing trust in public health. Give me a break.
        taolegal 4y ago
        If you're going to unveil a new vaccine it should be proven to be effective. Anything else at this point (when practically everyone has developed an immune response through infection or previous vaccination) is unethical. The mouse models were challenge studies, i.e. how do vaccinated mice respond to exposure to the omicron variant? That's what matters. Versus what you are demagoguing. Conflating with "tested", that since the new booster was given to humans and no abnormal AEs were observed & antibody levels rose, that automatically means it must be effective. This is precisely the scenario that degrades public trust in institutions when this fast-and-loose science is being rolled-out live on large populations.
- spookthesunset 4y ago
  It doesn’t require a conspiracy to think something is majorly wrong with how the last 2.5 years were handled. Everybody played to their incentives and thought they were doing the right thing. The outcome was a complete disaster and a horrific overreaction. But people thought they were doing the right thing. It’s kind of like a modern engineering failure. It takes multiple failures to bring down complex, redundant systems. That is what happened here. > when all the science and data is out there in the open, just ignored. I lost count of the number of times somebody yelled or called me “dangerous” for showing this data. Most of the public data goes directly against the narrative people like to push. It gets tossed right into the “conspiracy” bin. Virtually nothing about our response was based on science or data.
  - peter422 4y ago
    > Virtually nothing about our response was based on science or data. Virtually nothing? So the thousands and thousands of studies on vaccines, treatments, mask policies, vaccine policies, school policies, air filtration techniques, etc, etc… those were just done for no reason? To say we live in an imperfect society with imperfect leaders and imperfect citizens is a fair point. Incorrect decisions were and continue to be made for political reasons or religious reasons or whatever else. That’s what happens in an imperfect society. To say “virtually nothing” about the response is based on data is just ridiculous. Again, anti-vaxxers and conspiracy theorists make up a world where decisions are made in secret for suspicious reasons when generally all the data and arguments are out in the open and are just ignored.
    - spookthesunset 4y ago
      > anti-vaxxers and conspiracy theorists Are all the highly esteemed professors, scientists, politicians, healthcare workers, and researchers who signed the great barrington declaration anti-vaxx conspiracy theorists? Do you have any idea how many people in real life yelled at me and called me incredibly nasty things for suggesting that maybe, just maybe this myopic fixation on Covid was going to have some serious long term effects and maybe, just maybe we are overreacting? You can’t speak against the narrative. Speaking out against what we did was and still is career suicide if you are in healthcare, science or research. There has been a continual incredibly strong push to label anything that goes against “the narrative” as misinformation, “anti-whatever”. Speaking out as a member of the medical/science community gets you blacklisted. Beware of any research that got published in the heat of this mess—there were strong incentives to only publish research that supported “the narrative”.
- omniglottal 4y ago
  Do not make such assumptions - it is against the guidelines and is abusive to the notion that we can engage in dialogue here in good faith.

omniglottal 4y ago

Why not plural microorganismS? Although a neglible increase of mortality across countless events where broad-acting immunity protects us may be outside your ability to calculate, it's still readily applicable to recognize that a lot of straw exists on a camel's back without simply studying just the one which broke it. An overall increase in mortality from all causes is congruent with valid scientific theory and is a hypothesis worth evaluating without eschewing existing data. Your question is unneccessarily leading with false premises by which you define the answer without accepting the known truth. If you're looking for just one organism which would need to spread, then you're looking in the wrong place for how, i.e., people were killed by myocarditis, or inability to stay nourished while suffering vaccine-induced side effects, including inability to defend with the same metabolic fervor from the flu.