3 ms·

The HN title seems to be somewhat misleadingly chopped. The study here showed that injection of a fake vaccine (coding for GFP) in mice appeared to reduce the

The HN title seems to be somewhat misleadingly chopped. The study here showed that injection of a fake vaccine (coding for GFP) in mice appeared to reduce the effectiveness of future vaccines (coding for influenza) that used the exact same delivery mechanism. Note that this a preprint, but appears to be accepted for publication, though may still undergo revisions to this draft.

kmeisthax 4y ago
So... exactly the same problem with adenovirus-vector vaccines, in that each vector virus is "burned" by the introduction of a vaccine using it? That's somewhat disappointing.
- manwe150 4y ago
  I think it was quite different from that in this study. This result appears to suggest that the mRNA remained an effective vaccine vector against new viruses, but suggested that it also slowed the body's immune response to an unrelated yeast infections in the week immediately after vaccination. If I understand correctly, they then also showed that vaccination pre-pregnancy has inheritable benefit to their offspring in reducing the severity of illness in their children.
  - Traubenfuchs 4y ago
    > If I understand correctly, they then also showed that vaccination pre-pregnancy has inheritable benefit to their offspring in reducing the severity of illness in their children. Mothers pass on all the antibodies they have in their blood and breast milk to the baby. This effect diminishes greatly after colostrum is gone and stops as soon as the baby is weaned. This can be considered an external immune system. Once the baby is weaned, it is fully vulnerable to all the diseases it might have been protected from by its mothers antibodies.
- Traubenfuchs 4y ago
  When vaccination was required to keep participating in social life this was my motivation to get a second JJ vaccine despite the pressure to get an mRNA vaccine. I assumed my immune system would have an easier time to remove it from my body.

kmeisthax 4y ago

So... exactly the same problem with adenovirus-vector vaccines, in that each vector virus is "burned" by the introduction of a vaccine using it? That's somewhat disappointing.

manwe150 4y ago
I think it was quite different from that in this study. This result appears to suggest that the mRNA remained an effective vaccine vector against new viruses, but suggested that it also slowed the body's immune response to an unrelated yeast infections in the week immediately after vaccination. If I understand correctly, they then also showed that vaccination pre-pregnancy has inheritable benefit to their offspring in reducing the severity of illness in their children.
- Traubenfuchs 4y ago
  > If I understand correctly, they then also showed that vaccination pre-pregnancy has inheritable benefit to their offspring in reducing the severity of illness in their children. Mothers pass on all the antibodies they have in their blood and breast milk to the baby. This effect diminishes greatly after colostrum is gone and stops as soon as the baby is weaned. This can be considered an external immune system. Once the baby is weaned, it is fully vulnerable to all the diseases it might have been protected from by its mothers antibodies.
Traubenfuchs 4y ago
When vaccination was required to keep participating in social life this was my motivation to get a second JJ vaccine despite the pressure to get an mRNA vaccine. I assumed my immune system would have an easier time to remove it from my body.