4 ms·
>LNP alone led to long-term inhibition of the adaptive immune response So it's the lipid capsule, not mRNA, that has an unknown effect on the immune system. Ma
by guardiangod 4y ago
>LNP alone led to long-term inhibition of the adaptive immune response
So it's the lipid capsule, not mRNA, that has an unknown effect on the immune system. Make sense as many pathogens have lipid proteins on their surface.
> the resistance of mice to heterologous infections with influenza virus increased while resistance to Candida albicans decreased.
Better in some, worse in others
>mice pre-exposed to the mRNA-LNP platform can pass down the acquired immune traits to their offspring, providing better protection against influenza.
What about candida albicans (might be no effect?)
- jcims 4y agoThis is a point that I think is being missed. It's about the package, not the product.
- BbzzbB 4y agoBut the package is part of the product that we, billions of people, took..
- jcims 4y agoI suppose. Obviously if these findings hold for humans we could all be impacted. I just think it's important to differentiate what is caused by the nanoparticle delivery mechanism and what is caused by the mRNA. For example it's not super clear (based on a quick scan) which part they are talking about with the notes on heritability.
- Izkata 4y ago> So it's the lipid capsule, not mRNA, that has an unknown effect on the immune system. Make sense as many pathogens have lipid proteins on their surface. They were too toxic to use as a delivery mechanism as recently as 2018. IIRC it somehow damaged cell walls. Around 2018/2019 there was some sort of breakthrough that eliminated most of the problem, but the article I read last year didn't even try to call them perfectly safe, just safe enough as far as we could tell. I think this was also the main reason that even though mRNA was being researched for decades, using it in a vaccine was a no-go until recently: We didn't have a working delivery mechanism.