3 ms·

Recently attended a lecture on Cannabis by a renowned researcher on the subject (the Director of the UCLA Center for Cannabis & Cannabinoids) The most adverse

by nico 4y ago

Recently attended a lecture on Cannabis by a renowned researcher on the subject (the Director of the UCLA Center for Cannabis & Cannabinoids) The most adverse (proven) effects of Cannabis are: * Frequent bronchitis (for people that smoke it) * Risk of vehicle crashes * Low pregnancy weight, preterm birth, NICU * Mental health (associated risk of schizophrenia, depression, anxiety, suicidal ideation, Cannabis use disorder) * Impaired learning, memory, attention * Drug-drug interaction (mostly for CBD - liver toxicity) That’s the complete slide. Not once in the whole lecture were heart rate issues mentioned or asked about by the attendees. As you can see, there are plenty of adverse effects, but heart-related issues are not one of the main concerns. Do you have any sources for the research you mention and how concerning it is?

sigstoat 4y ago
some haphazardly chosen references from a 2013 bibliography on the subject, compiled by someone who probably doesn't want her name showing up in an internet forum. Aryana A, Williams MA. Marijuana as trigger of cardiovascular events: speculation or scientific certainty? Int J Cardiol 2007;118:141-4. https://doi.org/10.1016/j.ijcard.2006.08.001 https://doi.org/10.1016/j.ijcard.2006.08.001 Bachs L, Morland H. Acute cardiovascular fatalities following cannabis use. Forensic Sci Int 2001;124:200-3. Cappelli F, Lazzeri C, Gensini GF, Valente S. Cannabis: a trigger for acute myocardial infarction? A case report. J Cardiovasc Med 2008;9:725-728. Jones RT. Cardiovascular system effects of marijuana. J Clin Pharmacol 2002; 42(11 Suppl.):58S-63. Sidney S. Cardiovascular consequences of marijuana use. J Clin Pharmacol 2002;42(11 Suppl.):64S-70S. (Found no association.) Tormey WP. Royal College of Pathologists’ autopsy guidelines on sudden cardiac death: roles for cannabis, cotinine, NSAIDs and psychology. J Clin Pathol 2012;65:187-188. so there's a starting place to look into it. maybe the intervening 9 years have demonstrated that it isn't an issue.
ch4s3 4y ago
> Frequent bronchitis (for people that smoke it) Yep breathing combustion products is pretty bad for you. > Risk of vehicle crashes I'm not aware of any proponents of driving while high. > Low pregnancy weight, preterm birth, NICU Again, who's advocating for pregnant women to consume cannabis? > Mental health (associated risk of schizophrenia, depression, anxiety, suicidal ideation, Cannabis use disorder) I think this is only for those already genetically predisposed to developing schizophrenia. > Impaired learning, memory, attention I'm not sure anyone thinks you should smoke a bunch of drugs before studying for finals. Just for an ounce of perspective here.
- brigandish 4y ago
  > I'm not aware of any proponents of driving while high. > Again, who's advocating for pregnant women to consume cannabis? I thought the comment was making clear what was considered a risk, not what is being advocated? People certainly do drive while under the effects of cannabis, I've known a few. I don't know anyone who consumed it while pregnant but I'm sure they do exist. > I'm not sure anyone thinks you should smoke a bunch of drugs before studying for finals. Again, I know people who've done this.
  - ch4s3 4y ago
    I think I mistook the intent of the original post.
    - brigandish 4y ago
      Fair enough
- RHSman2 4y ago
  Ounce. Touché
tsol 4y ago
There's some evidence to point that heart issues are more common in marijuana smokers. https://med.stanford.edu/news/all-news/2022/04/marijuana-heart-disease.html#:~:text=People%20who%20smoke%20marijuana%20more,and%20their%20colleagues%20have%20found.&text=People%20who%20use%20marijuana%20have,by%20researchers%20at%20Stanford%20Medicine https://med.stanford.edu/news/all-news/2022/04/marijuana-hea.... https://www.heart.org/en/news/2021/11/08/cannabis-use-disorder-may-be-linked-to-growing-number-of-heart-attacks-in-younger-adults https://www.heart.org/en/news/2021/11/08/cannabis-use-disord...
scythe 4y ago
Bronchitis? I've known a lot of marijuana smokers, and I don't recall any of them ever having bronchitis. >Mental health (associated risk of schizophrenia, depression, anxiety, suicidal ideation, Cannabis use disorder) Small but >1 ORs for a rare disorder like schizophrenia (base rate ~0.02%) sound scarier than they really are. Many recreational activities are associated with a similar increase in the risk of concussion (base rate ~1%), and yet they are actually recommended for general health. Correlation of recreational drug use with depression/anxiety has a causal direction problem. Others in this thread have linked studies about the effects on the heart. It remains to be seen what the long-term risk profile is.
snarfy 4y ago
That might be the complete slide but it is not the complete picture. This disorder for example causes pretty extreme digestive issues, and it has not been in the medical literature for very long. https://en.wikipedia.org/wiki/Cannabinoid_hyperemesis_syndrome https://en.wikipedia.org/wiki/Cannabinoid_hyperemesis_syndro...
fsociety 4y ago
I am skeptical about this researcher as it does not mention decreased gut motility and CHS in rare instances.

by nico 4y ago

sigstoat 4y ago

some haphazardly chosen references from a 2013 bibliography on the subject, compiled by someone who probably doesn't want her name showing up in an internet forum. Aryana A, Williams MA. Marijuana as trigger of cardiovascular events: speculation or scientific certainty? Int J Cardiol 2007;118:141-4. https://doi.org/10.1016/j.ijcard.2006.08.001 https://doi.org/10.1016/j.ijcard.2006.08.001 Bachs L, Morland H. Acute cardiovascular fatalities following cannabis use. Forensic Sci Int 2001;124:200-3. Cappelli F, Lazzeri C, Gensini GF, Valente S. Cannabis: a trigger for acute myocardial infarction? A case report. J Cardiovasc Med 2008;9:725-728. Jones RT. Cardiovascular system effects of marijuana. J Clin Pharmacol 2002; 42(11 Suppl.):58S-63. Sidney S. Cardiovascular consequences of marijuana use. J Clin Pharmacol 2002;42(11 Suppl.):64S-70S. (Found no association.) Tormey WP. Royal College of Pathologists’ autopsy guidelines on sudden cardiac death: roles for cannabis, cotinine, NSAIDs and psychology. J Clin Pathol 2012;65:187-188. so there's a starting place to look into it. maybe the intervening 9 years have demonstrated that it isn't an issue.

ch4s3 4y ago

> Frequent bronchitis (for people that smoke it) Yep breathing combustion products is pretty bad for you. > Risk of vehicle crashes I'm not aware of any proponents of driving while high. > Low pregnancy weight, preterm birth, NICU Again, who's advocating for pregnant women to consume cannabis? > Mental health (associated risk of schizophrenia, depression, anxiety, suicidal ideation, Cannabis use disorder) I think this is only for those already genetically predisposed to developing schizophrenia. > Impaired learning, memory, attention I'm not sure anyone thinks you should smoke a bunch of drugs before studying for finals. Just for an ounce of perspective here.

brigandish 4y ago
> I'm not aware of any proponents of driving while high. > Again, who's advocating for pregnant women to consume cannabis? I thought the comment was making clear what was considered a risk, not what is being advocated? People certainly do drive while under the effects of cannabis, I've known a few. I don't know anyone who consumed it while pregnant but I'm sure they do exist. > I'm not sure anyone thinks you should smoke a bunch of drugs before studying for finals. Again, I know people who've done this.
- ch4s3 4y ago
  I think I mistook the intent of the original post.
  - brigandish 4y ago
    Fair enough
RHSman2 4y ago
Ounce. Touché

tsol 4y ago

There's some evidence to point that heart issues are more common in marijuana smokers. https://med.stanford.edu/news/all-news/2022/04/marijuana-heart-disease.html#:~:text=People%20who%20smoke%20marijuana%20more,and%20their%20colleagues%20have%20found.&text=People%20who%20use%20marijuana%20have,by%20researchers%20at%20Stanford%20Medicine https://med.stanford.edu/news/all-news/2022/04/marijuana-hea.... https://www.heart.org/en/news/2021/11/08/cannabis-use-disorder-may-be-linked-to-growing-number-of-heart-attacks-in-younger-adults https://www.heart.org/en/news/2021/11/08/cannabis-use-disord...

scythe 4y ago

Bronchitis? I've known a lot of marijuana smokers, and I don't recall any of them ever having bronchitis. >Mental health (associated risk of schizophrenia, depression, anxiety, suicidal ideation, Cannabis use disorder) Small but >1 ORs for a rare disorder like schizophrenia (base rate ~0.02%) sound scarier than they really are. Many recreational activities are associated with a similar increase in the risk of concussion (base rate ~1%), and yet they are actually recommended for general health. Correlation of recreational drug use with depression/anxiety has a causal direction problem. Others in this thread have linked studies about the effects on the heart. It remains to be seen what the long-term risk profile is.

snarfy 4y ago

That might be the complete slide but it is not the complete picture. This disorder for example causes pretty extreme digestive issues, and it has not been in the medical literature for very long. https://en.wikipedia.org/wiki/Cannabinoid_hyperemesis_syndrome https://en.wikipedia.org/wiki/Cannabinoid_hyperemesis_syndro...

fsociety 4y ago

I am skeptical about this researcher as it does not mention decreased gut motility and CHS in rare instances.