They all change PATH somehow. Which one you use depends on your use case. I, for instance, prefer pyenv for having a runtime and package set that covers most of

They all change PATH somehow. Which one you use depends on your use case. I, for instance, prefer pyenv for having a runtime and package set that covers most of my projects and virtualenvs for test sandboxes of new package versions. Conda, for instance, is great for ML and scientific given the extra niceties for replicating environments, but most specifically because you get package sets optimized for your analysis needs.