Believing that laboratory-made organisms somehow obey different laws than nature-made organisms is exactly the sort of hubris I was alluding to. There absolutel

Believing that laboratory-made organisms somehow obey different laws than nature-made organisms is exactly the sort of hubris I was alluding to. There absolutely is a genetic impediment to a virus that is both easily spread and deadly. Biological organisms are highly complex, non-linear, stochastic systems. You can resist malaria, but you'll get sickle cell disease. You might suffer from high prevalence of Cystic Fibrosis, but your population can better resist cholera. Biological variables are, essentially, never independent. This is why systems biology is such a difficult area to study. Oh, and those mice that glow in the dark might look cool in the lab, but they'd be the first to get eaten in the wild. There's a reason mice don't naturally glow in the dark...