4 ms·
From the linked Nature article, my layman's interpretation is it seems a more severe finding (CHIP) was not found (and was possibly what they were looking for a
by gz5 4y ago
From the linked Nature article, my layman's interpretation is it seems a more severe finding (CHIP) was not found (and was possibly what they were looking for as CHIP may have indicated a potentially more material impact), and that this is more like an early, thin data set which can't be fully evaluated without more data:
>We identified 34 nonsynonymous SNVs in 17 known CHdriver genes, of which TP53 and DNMT3A were the most frequent. Notably, clone size was small, ranging from 0.10% to 0.95% VAF, and thus did not achieve the technical threshold to be
considered as CHIP
and
>Due to the lack of longitudinal samples and small sample size,
conclusions regarding the implications of observed lesions remain
limited, and further studies are required to assess the penetrance
of these clones.
Is that how the rest of you read this, especially those of you who are more expert?
- michaericalribo 4y agoI agree; that is basically my take, with two slight amendments: I didn’t have the sense there was a value judgement (more/less severe), so much as that CHIP is “typical” mutation seen in the wider population, associated with aging (itself a fascinating field of research), whereas something novel / nonstandard is causing CH mutations (space?? That’s the implication). On sample size, I read it as “this is interesting preliminary work that is surprisingly robust for the sample we have, and thus intrinsically notable.” But the passage you cite and the surrounding discussion indicates that this is far from conclusive—it’s a promising / interesting direction for more research to find out what’s the “there” there, if anything. These things _could_ be coincidental, but such a high rate of consistency is strong signal to investigate further. This paper propagates that surprising result, which is also a unique analysis because of the lack of data the authors acknowledge. Without publishing this, others would have no access to even this preliminary finding.
- Nokinside 4y agoNASA astronauts Mark and Scott Kelly are identical twins and scientists took the opportunity to do extensive tests with them. One pair of twins is not conclusive but the study is interesting. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight https://www.science.org/doi/10.1126/science.aau8650 https://www.science.org/doi/10.1126/science.aau8650 NASA Twins Study Confirms Preliminary Findings https://www.nasa.gov/feature/nasa-twins-study-confirms-preliminary-findings https://www.nasa.gov/feature/nasa-twins-study-confirms-preli...