Pythran and Nuitka have very different philosophies and goals. Pythran aims for performance first, and to achieve that it is willing to sacrifice a lot of compa

Pythran and Nuitka have very different philosophies and goals. Pythran aims for performance first, and to achieve that it is willing to sacrifice a lot of compatibility and supports only a small subset of python. Taking a random piece of python code and trying to run it under pythran will almost certainly fail. To get the most out of Pythran you really have to write 'pythran' code rather than 'python' code. Nuitka aims for 100% compatibility first. If you have some random python code that works under CPython, but not Nuitka, then that is a bug that will be fixed. To achieve this compatibility there are a lot of optimisations that cannot be done. If you have code that works under both Nuitka and Pythran then it will almost certainly be faster in Pythran.