For the most recent application I tried Pythran on, significantly annotated Cython was the winner (compared to plain Python, Numba, Pythran, and more readable C

For the most recent application I tried Pythran on, significantly annotated Cython was the winner (compared to plain Python, Numba, Pythran, and more readable Cython). Plain Python was the slowest, and Pythran was much slower than the others. I didn't try Nuitka for it. I ended up rewriting the key code in C anyway, which was faster still. This was integer numerical code filling in a 2D array with lots of comparisons and backtracking.