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Albert Hoffman discovered LSD by accidentally absorbing it through his fingertips. [0] > While re-synthesizing LSD, he accidentally absorbed a small amount of

Albert Hoffman discovered LSD by accidentally absorbing it through his fingertips. [0] > While re-synthesizing LSD, he accidentally absorbed a small amount of the drug through his fingertips and discovered its powerful effects. [0] https://en.wikipedia.org/wiki/History_of_LSD#Discovery https://en.wikipedia.org/wiki/History_of_LSD#Discovery

notch656a 4y ago
How much was Hoffman working with though? The absorptivity needn't be high when the potency is so high.
- pengaru 4y ago
  From LSD - My Problem Child, pt. "Discovery of the Psychic Effects of LSD": "Nevertheless, in the spring of 1943, I repeated the synthesis of LSD-25. As in the first synthesis, this involved the production of only a few centigrams of the compound." "In the final step of the synthesis, during the purification and crystallization of lysergic acid diethylamide in the form of a tartrate (tartaric acid salt), I was interrupted in my work by unusual sensations." ... "But this led to another question: how had I managed to absorb this material? Because of the known toxicity of ergot substances, I always maintained meticulously neat work habits. Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin. If LSD-25 had indeed been the cause of this bizarre experience, then it must be a substance of extraordinary potency."
  - notch656a 4y ago
    Enjoyed the excerpts and thank you! I take a few to mean more than 2 centigrams. So 30mg minimum. Thats 300x the 'normal' dose.
  - bryanrasmussen 4y ago
    so Hoffman doesn't actually know how he absorbed it >Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin. that's a possibly, I suppose if that possibly exists then possibly some got on object X and then after leaving lab object X came in contact with his mouth or even nose when he touched his face.

notch656a 4y ago

How much was Hoffman working with though? The absorptivity needn't be high when the potency is so high.

pengaru 4y ago
From LSD - My Problem Child, pt. "Discovery of the Psychic Effects of LSD": "Nevertheless, in the spring of 1943, I repeated the synthesis of LSD-25. As in the first synthesis, this involved the production of only a few centigrams of the compound." "In the final step of the synthesis, during the purification and crystallization of lysergic acid diethylamide in the form of a tartrate (tartaric acid salt), I was interrupted in my work by unusual sensations." ... "But this led to another question: how had I managed to absorb this material? Because of the known toxicity of ergot substances, I always maintained meticulously neat work habits. Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin. If LSD-25 had indeed been the cause of this bizarre experience, then it must be a substance of extraordinary potency."
- notch656a 4y ago
  Enjoyed the excerpts and thank you! I take a few to mean more than 2 centigrams. So 30mg minimum. Thats 300x the 'normal' dose.
- bryanrasmussen 4y ago
  so Hoffman doesn't actually know how he absorbed it >Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin. that's a possibly, I suppose if that possibly exists then possibly some got on object X and then after leaving lab object X came in contact with his mouth or even nose when he touched his face.