2 ms·
Here's the full paper: https://reader.elsevier.com/reader/sd/pii/S0264410X22010283 https://reader.elsevier.com/reader/sd/pii/S0264410X22010283 As I understand
by em500 4y ago
Here's the full paper: https://reader.elsevier.com/reader/sd/pii/S0264410X22010283 https://reader.elsevier.com/reader/sd/pii/S0264410X22010283
As I understand it, these are results from two different trials done separately by Pfizer and Moderna, with slightly different protocols and reporting standards:
"Moderna reported SAEs [serious adverse effects] from dose 1 whereas Pfizer limited reporting from dose 1 to 1 month after dose 2."
"For reasons that are not documented in the trial protocol, Moderna included efficacy outcomes in its SAE tabulations, while Pfizer excluded them. As a result, Moderna’s SAE table did not present a traditional SAE analysis but rather an all-cause SAE analysis. "
Thus, only numerical comparisons between treatment and control within the same trial are valid (assuming proper randomization), not between the two trials.
- rurban 4y agohttps://www.sciencedirect.com/science/article/pii/S0264410X22010283?via%3Dihub https://www.sciencedirect.com/science/article/pii/S0264410X2... Pfizer reported serious adverse effects in 127 vaccine and 93 placebo. Moderna reported serious adverse effects in 206 vaccine and 195 placebo. => Headline: "Serious adverse events of special interest following placebo vaccination in randomized trials in adults"
- LorenPechtel 4y agoNormally there aren't competing drugs racing to market, thus the FDA doesn't have any system in place to ensure apples-to-apples comparisons in a case like this. Each company decides it's test protocols and gets FDA approval, they aren't working in cooperation.