This is emphatically not true for USB interfaces in general. In particular, the first readily available set of benchmark results I was able to find[1] suggest

This is emphatically not true for USB interfaces in general. In particular, the first readily available set of benchmark results I was able to find[1] suggest the difference in audio (not MIDI) latency between the lowest-latency PCIe cards and the listed USB devices (RME Fireface UFX+ USB3 and RME Babyface Pro [USB2]) is under a millisecond. While I couldn't find similar results for MIDI I/O, it seems unlikely that either of these USB devices' MIDI interfaces would introduce an order of magnitude more latency than their audio counterparts. [1] https://gearspace.com/board/showpost.php?p=15796206&postcount=5092 https://gearspace.com/board/showpost.php?p=15796206&postcoun...