You left out lead poisoning (unless that's included in "self inflicted accidental poisoning"). Yeah, everything that could go wrong did go wrong. We can't run

You left out lead poisoning (unless that's included in "self inflicted accidental poisoning"). Yeah, everything that could go wrong did go wrong. We can't run a natural experiment where everything but that one thing goes wrong, and see if Rome survives. Kind of like a very old organism whose health just goes off the cliff.