7 ms·
Team developing oral insulin tablet sees breakthrough results in rats
- faeriechangling 4y ago
- a_t48 4y agoWe could have also inferred that he’s a doctor, but make it unambiguous anyhow.
- faeriechangling 4y agoHow would it have been ambiguous!
- deleted 4y ago[deleted]
- earleybird 4y agoWell, there it is. I now feel fully justified to claim my pronoun is 10xdev. Obviously there are folks who are pretty sure I'm not a 10x dev but that doesn't matter, it's what I believe. :-)
- tragictrash 4y agoWhat's the other pronoun?
- earleybird 4y agoI believe it's its own plural :-)
- tragictrash 4y agoTouche :D
- throwmeaway1212 4y agoIt's about normalising it for people to make it better for others. This tweet sums it up well https://twitter.com/aaronhoyland/status/1564621817360556042 https://twitter.com/aaronhoyland/status/1564621817360556042
- tragictrash 4y ago
- dang 4y agoOuch, you've been breaking the site guidelines so often and so egregiously that I think we have to ban the account. I've therefore done so. If you don't want to be banned, you're welcome to email hn@ycombinator.com and give us reason to believe that you'll follow the rules in the future. They're here: https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html.
- dang 4y ago"Eschew flamebait. Avoid unrelated controversies and generic tangents." "Please don't pick the most provocative thing in an article or post to complain about in the thread. Find something interesting to respond to instead." https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html
- bilsbie 4y agoCould non diabetics take this? Would it help with weight loss or mitigating a large sugar spike?
- TylerE 4y agoDangerous, and would be of limited benefit. Being non-diabetic means your body makes enough. Taking insulin on top of that could easily drive you into unconsciousness and even death. Low blood sugar is NO JOKE. If you're interested in this line of thinking, metformin is probably both more promising, as well as substantially cheaper and far safer - it basically increases your body's sensitivity to insulin, without actually mucking with production/regulation of same.
- galangalalgol 4y agoDoesn't berberine do something similar? Dhea too?
- TylerE 4y agoDunno, I'm only a patient, not a doctor.
- beached_whale 4y agoInsulin causes weight gain.
- robobro 4y agoSome body builders take insulin to help build muscles!
- beached_whale 4y agoI think, dont know, they used it so the body would absorb glucose right after a workout instead of breaking down muscle. But fat storage is part of that too. I suspect because they are using the energy that isnt a concern. But super dangerous and in most cases outside body building it leads to weight free gain. It is often difficult for type1 diabetics to lose weight and some go down another dangerous path of reducing their insulin without increasing their sensitivity.
- pg_bot 4y agoFunnily enough, if you don't like injections insulin can also be insufflated (inhaled) as a dry powder. Affreza[0] has been on the market for some time, but hasn't caught on. Pills/tablets are a more acceptable delivery mechanism for most people, but I can't help wonder if making insulin like a Goody's powder would be better. Instead of swallowing it just keep a powder next to your cheek and let it absorb into your system. [0]: https://afrezza.com/ https://afrezza.com/
- ninjin 4y agoType-1 diabetic. I am not sure how much this will change the situation in the richer parts of the world, as tablets still seem inferior to me compared to pump deliver (my current method of choice). As pumps in terms of fast-acting (bolus) insulin will still allow for finer granularity delivery (tablets will come with fixed dosages and most likely never as small as say 0.1 units which is ~1/100 of the dosage I use for a “standard meal”), less delay between injection and effect as it does not pass through your digestive tract, and I suspect (not a medical doctor) that it may be more reliable in terms of uptake as your stomach uptake rate at least for carbohydrates depends on things like what you have eaten earlier during the day. Furthermore, pumps also allow for better control over your long-acting (basal) insulin rates which can be programmed or temporarily altered if you say skip a meal. However, I still think this can mean a world of difference for those in less sanitary conditions, those who are uncomfortable with having a device attached to them at all times, and those in places where relying on a technology supply chain is not feasible. Heck! Even pump users need to have emergency insulin at hand in case our pumps break; I would take tablets any day over the complexity of injections.
- metaphor 4y ago> I am not sure how much this will change the situation in the richer parts of the world, as tablets still seem inferior to me compared to pump deliver (my current method of choice). I'm not a diabetic, but is there really anything on the market even comparable to what the researchers here are suggesting, that is, dissolved (not swallowed) insulin pill delivery with performance equivalent to rapid-acting injection?
- robobro 4y agoI tend to use between 1 insulin unit and 15 for meals. I don't want to take 15 little pills for that meal with more carbohydrates. What if I need 8 units of insulin for a meal? Do I need to take a 5 unit pill and three 1 unit pills? Too much work, no thanks, let me just take the little shot in all of 3 seconds in my tummy. I live in Indonesia where the weather can exceed the safe storage temperature for insulin; it is a pain in the ass keeping my extra insulin cold when there's a power storage (unopened insulin needs to stay in the fridge until it's ready to use). So pills would be better than vials for this reason. In terms of every day convenience though, shots really aren't that bad after you've had enough. By a rough estimate, I've given myself over 25,000 shots in my life. That is a lot of used syringes and medical waste, but my point is, shots aren't that big of a deal for most diabetics. Insulin pens[1] are very convenient. They fit in your pocket, and you just dial the dose, poke yourself, push the button, done. Aside from having to keep them cool, I have no motivation at all to switch to a less convenient system. [1] https://www.youtube.com/watch?v=XTXzTDUf6rc https://www.youtube.com/watch?v=XTXzTDUf6rc
- Gatsky 4y agoI wish I was one hundredth as optimistic as University press release drivel.
- hulitu 4y ago> Team developing oral insulin tablet sees breakthrough results in rats Team fixing the effect instead of the cause. Eat more sugar.
- feet 4y agoBecause type 1 diabetics don't exist?