It's definitely not a one-time thing... There's a fascinating Radiolab episode on the the history of Rapomycin, including discussions of the mechanism of action

It's definitely not a one-time thing... There's a fascinating Radiolab episode on the the history of Rapomycin, including discussions of the mechanism of action: https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub The basic hypothesis is that cells operate in two modes, one storing up stuff in times of plenty, and a second mode which uses up the stores and cleans up, active during lean times. mTor is supposed to be the chemical signal which indicates which mode to act in; it's inhibited by both fasting and rapomycin.