4 ms·

Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic.

Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.

colechristensen 4y ago
The super unpleasant part of fasting is a phase that ends.
kubami 4y ago
I fast a lot, right now I do 36 - 72h every 6 - 8 weeks. The hardest moment is right when your body is about to switch from using glucose to using ketone bodies for energy. After that the hunger, feeling anxious, etc stops. The time it takes to get to that point (when feeling "bad" intensifies) and how long the transition takes can be influenced. Primarily, by what you eat before you fast. In general, avoid eating carbohydrates, especially simple carbohydrates like sugar, fruits, past, bread, etc. I usually eat more protein and fat before fasting. Another "trick" during fasting is to cheat your stomach a bit by filling it with liquids - I drink lots of water and tea. The main thing to remember - it will pass, and you will feel great after your body switches. Your mind will tell you that it will just progressively get worse the deeper you get into the fast - it's not true :)
- yazaddaruvala 4y ago
  Oh I forgot about the tricks. Thanks. I also use the tricks mentioned above. They are very useful. Additional tricks: - Use fiber supplements in your water sometime in the middle of your fast (simplest time is in the morning in lieu of breakfast). I use psyllium husk. - Soup (or rather broth) is a fasting bff. Remember miso, herbs, spices, salt, do not have calories. Flavor your water liberally. Change up the consistency with stuff in it (green onions, seaweed). Change up the temperature (hot, cold, whatever). I even add psyllium husk to my soups to change up the texture and consistency just for the variety. Remember you can “eat” a lot of tasty stuff while still technically fasting. - Actively (rather than passively) deplete your glycogen stores. Do a workout ideally including cardio, then do your best to immediately fall asleep to recover. I can sleep through anything, if you can too you’ll be in keto by the morning and no real feelings of difficulty. - Remember to take a multi-vitamin daily while fasting. Make sure it doesn’t have sugar like those “vitamin C hangover powders” or “electrolyte water stuff like Gatorade”.
  - adamgordonbell 4y ago
    Great tips. I'm going to try having more soup.
- yamtaddle 4y ago
  I've dabbled in fasting and found my ability to do it comfortably varies a ton day-to-day. Some days I'm craving food by noon and/or am very tired and practically can't think at all by 3PM (this is pretty bad on work days, obviously, but not really great on any day). Other days I can go from wake-up to lie-down without a single bite of food, and hardly notice a thing. I can't tell in advance which it's going to be, so rather than sticking hard to a fasting schedule, when I'm in the mood to do it I'll pick days to try, and if at some point it becomes clear I'm gonna wreck my whole day if I persist, I bail and eat a meal. Ends up being about 50/50, days that work out and days that don't, if I try a couple days per week. Sometimes I can approach 48 hours before I start to feel bad, other times I can't even make it one day before I'm a mess and can hardly function. I'm sure the difference has to do with blood sugar timing and/or what I ate the day before or something.
yazaddaruvala 4y ago
Human bodies are crazy cool. 1. There is some internal clock that we don’t yet understand but clearly exists. Specifically your digestive track proactively activates itself in preparation for food. Then if food doesn’t come, your stomach will “growl”. It takes a 1-3 months for your clock to readjust such that it doesn’t do that. After this you will not “feel hungry”. If you intermittently fast for a year or so, you will likely never again “feel hungry”. 2. Eating meals is a habit. Arguably more addictive than smoking. But like with any habit, it can be broken. This isn’t the feeling of hunger… rather a weird compulsion. If you stop fasting for a few months, this will need to be rebroken every time. I’m currently struggling to re-break it. 3. The social pressure to eat is real! This is the hardest to contend with. Good luck :)
- mordechai9000 4y ago
  On point #3: there seems to be something about being on any kind of restricted diet that makes people want to feed you.
fayalargeau 4y ago
that was my favorite podcast, but he did say that he stays away from it because it's meant for people who need it as an immunosuppresant
runnerup 4y ago
> Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating. Different people have different responses to fasting. It's always been very easy for me to fast by becoming "at peace" with the feeling of hunger for the first 2-3 days, and after that I don't even notice. But later in life something about my body changed and my response to fasting was much more severe and I was suddenly unable to fast for more than 1-2 days due to extremely strong urges to eat, irritability, etc. This happened for 2-3 attempted fasts around the age of 32. A year or two later, and fasting is suddenly "easy" for me again. To be clear, the first 2-3 days usually sucks regardless. I suspect that I am generally very good at metabolizing fat. When I get blood tests while fasting, even if I haven't eaten anything at all in 7 days, my glucose is generally still well above the minimum of normal, even sometimes towards the high side. I suspect that if my blood sugar was low, I'd have much more difficulty. It does seem to take 2-3 days for my body to "switch" to metabolizing fat at a high enough rate to raise my blood sugar up. I also suspect different people have very different reactions to low blood sugar. Just as a note, for me one of the biggest determinants of a successful fast is control over my environment. If there are people in my home cooking great food every night at the same time, it's very hard. If I'm living alone and let my fridge get empty, it's much easier. I've also dealt with it by shifting my work hours to leave later and come home after my partner has finished dinner and cleaned up the kitchen. But this is orthogonal to the above issue.

colechristensen 4y ago

The super unpleasant part of fasting is a phase that ends.

kubami 4y ago

I fast a lot, right now I do 36 - 72h every 6 - 8 weeks. The hardest moment is right when your body is about to switch from using glucose to using ketone bodies for energy. After that the hunger, feeling anxious, etc stops. The time it takes to get to that point (when feeling "bad" intensifies) and how long the transition takes can be influenced. Primarily, by what you eat before you fast. In general, avoid eating carbohydrates, especially simple carbohydrates like sugar, fruits, past, bread, etc. I usually eat more protein and fat before fasting. Another "trick" during fasting is to cheat your stomach a bit by filling it with liquids - I drink lots of water and tea. The main thing to remember - it will pass, and you will feel great after your body switches. Your mind will tell you that it will just progressively get worse the deeper you get into the fast - it's not true :)

yazaddaruvala 4y ago
Oh I forgot about the tricks. Thanks. I also use the tricks mentioned above. They are very useful. Additional tricks: - Use fiber supplements in your water sometime in the middle of your fast (simplest time is in the morning in lieu of breakfast). I use psyllium husk. - Soup (or rather broth) is a fasting bff. Remember miso, herbs, spices, salt, do not have calories. Flavor your water liberally. Change up the consistency with stuff in it (green onions, seaweed). Change up the temperature (hot, cold, whatever). I even add psyllium husk to my soups to change up the texture and consistency just for the variety. Remember you can “eat” a lot of tasty stuff while still technically fasting. - Actively (rather than passively) deplete your glycogen stores. Do a workout ideally including cardio, then do your best to immediately fall asleep to recover. I can sleep through anything, if you can too you’ll be in keto by the morning and no real feelings of difficulty. - Remember to take a multi-vitamin daily while fasting. Make sure it doesn’t have sugar like those “vitamin C hangover powders” or “electrolyte water stuff like Gatorade”.
- adamgordonbell 4y ago
  Great tips. I'm going to try having more soup.
yamtaddle 4y ago
I've dabbled in fasting and found my ability to do it comfortably varies a ton day-to-day. Some days I'm craving food by noon and/or am very tired and practically can't think at all by 3PM (this is pretty bad on work days, obviously, but not really great on any day). Other days I can go from wake-up to lie-down without a single bite of food, and hardly notice a thing. I can't tell in advance which it's going to be, so rather than sticking hard to a fasting schedule, when I'm in the mood to do it I'll pick days to try, and if at some point it becomes clear I'm gonna wreck my whole day if I persist, I bail and eat a meal. Ends up being about 50/50, days that work out and days that don't, if I try a couple days per week. Sometimes I can approach 48 hours before I start to feel bad, other times I can't even make it one day before I'm a mess and can hardly function. I'm sure the difference has to do with blood sugar timing and/or what I ate the day before or something.

yazaddaruvala 4y ago

Human bodies are crazy cool. 1. There is some internal clock that we don’t yet understand but clearly exists. Specifically your digestive track proactively activates itself in preparation for food. Then if food doesn’t come, your stomach will “growl”. It takes a 1-3 months for your clock to readjust such that it doesn’t do that. After this you will not “feel hungry”. If you intermittently fast for a year or so, you will likely never again “feel hungry”. 2. Eating meals is a habit. Arguably more addictive than smoking. But like with any habit, it can be broken. This isn’t the feeling of hunger… rather a weird compulsion. If you stop fasting for a few months, this will need to be rebroken every time. I’m currently struggling to re-break it. 3. The social pressure to eat is real! This is the hardest to contend with. Good luck :)

mordechai9000 4y ago
On point #3: there seems to be something about being on any kind of restricted diet that makes people want to feed you.

fayalargeau 4y ago

that was my favorite podcast, but he did say that he stays away from it because it's meant for people who need it as an immunosuppresant

runnerup 4y ago

> Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating. Different people have different responses to fasting. It's always been very easy for me to fast by becoming "at peace" with the feeling of hunger for the first 2-3 days, and after that I don't even notice. But later in life something about my body changed and my response to fasting was much more severe and I was suddenly unable to fast for more than 1-2 days due to extremely strong urges to eat, irritability, etc. This happened for 2-3 attempted fasts around the age of 32. A year or two later, and fasting is suddenly "easy" for me again. To be clear, the first 2-3 days usually sucks regardless. I suspect that I am generally very good at metabolizing fat. When I get blood tests while fasting, even if I haven't eaten anything at all in 7 days, my glucose is generally still well above the minimum of normal, even sometimes towards the high side. I suspect that if my blood sugar was low, I'd have much more difficulty. It does seem to take 2-3 days for my body to "switch" to metabolizing fat at a high enough rate to raise my blood sugar up. I also suspect different people have very different reactions to low blood sugar. Just as a note, for me one of the biggest determinants of a successful fast is control over my environment. If there are people in my home cooking great food every night at the same time, it's very hard. If I'm living alone and let my fridge get empty, it's much easier. I've also dealt with it by shifting my work hours to leave later and come home after my partner has finished dinner and cleaned up the kitchen. But this is orthogonal to the above issue.