3 ms·

As long as you can bear it. Which for me has been 24 +/- 4 hours between meals for 9 months and counting.

by orangepurple 4y ago

aaaaaaaaaaab 4y ago
And what conditions did you cure with this regime? Did your overall calorie intake remain the same?
- orangepurple 4y ago
  Benign tumors on my skin disappeared and I lost 80 pounds
  - moffkalast 4y ago
    https://c.tenor.com/rI48-HMbEaMAAAAC/spaceballs-lost.gif https://c.tenor.com/rI48-HMbEaMAAAAC/spaceballs-lost.gif
  - vxNsr 4y ago
    What is your current height and weight? If I were to lose 80lbs I would become emaciated.
    - aidenn0 4y ago
      And if I lost 80lbs I would be on the low-side of "normal weight" by BMI.
  - aaaaaaaaaaab 4y ago
    Benign tumors? Moles?
JumpCrisscross 4y ago
> long as you can bear it This gives zero evidence a threshold has been reached for enzyme activation. There is evidence of effects after 72 hours of fasting [1]. But we also know of counter-effects around 24 hours, when glucose released by the liver breaking down amino acids from muscle wasting (EDIT: autophagy) partially reactivates mTOR [2]. It could be massive or minimal benefits through 24 hours, we don't know, benefits which reduce between 24 hours and some other number, and then increase until, or until right before or well through 72 hours. [1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102031 https://journals.plos.org/plosone/article?id=10.1371/journal... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390257/?_escaped_fragment_=po=7.95455 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390257/?_escap...
- orangepurple 4y ago
  I wouldn't call protein breakdown in the muscle "wasting" without additional effects
  - JumpCrisscross 4y ago
    > wouldn't call protein breakdown in the muscle "wasting" without additional effects Fair enough, given it's voluntary [1]. It's biologically identical to wasting, however. [1] https://en.wikipedia.org/wiki/Wasting https://en.wikipedia.org/wiki/Wasting
    - wang_li 4y ago
      There's some evidence that exercising during the fast helps minimize the loss of muscle.
      - JumpCrisscross 4y ago
        > some evidence that exercising during the fast helps minimize the loss of muscle The original point was autophagy reactivates mTOR. This isn’t a linear system. It could be that a 20-hour fast downregulates mTOR more than a 30-hour fast. (We know it works at 72 hours.)

As long as you can bear it. Which for me has been 24 +/- 4 hours between meals for 9 months and counting.

aaaaaaaaaaab 4y ago

And what conditions did you cure with this regime? Did your overall calorie intake remain the same?

orangepurple 4y ago
Benign tumors on my skin disappeared and I lost 80 pounds
- moffkalast 4y ago
  https://c.tenor.com/rI48-HMbEaMAAAAC/spaceballs-lost.gif https://c.tenor.com/rI48-HMbEaMAAAAC/spaceballs-lost.gif
- vxNsr 4y ago
  What is your current height and weight? If I were to lose 80lbs I would become emaciated.
  - aidenn0 4y ago
    And if I lost 80lbs I would be on the low-side of "normal weight" by BMI.
- aaaaaaaaaaab 4y ago
  Benign tumors? Moles?

JumpCrisscross 4y ago

> long as you can bear it This gives zero evidence a threshold has been reached for enzyme activation. There is evidence of effects after 72 hours of fasting [1]. But we also know of counter-effects around 24 hours, when glucose released by the liver breaking down amino acids from muscle wasting (EDIT: autophagy) partially reactivates mTOR [2]. It could be massive or minimal benefits through 24 hours, we don't know, benefits which reduce between 24 hours and some other number, and then increase until, or until right before or well through 72 hours. [1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102031 https://journals.plos.org/plosone/article?id=10.1371/journal... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390257/?_escaped_fragment_=po=7.95455 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390257/?_escap...

orangepurple 4y ago
I wouldn't call protein breakdown in the muscle "wasting" without additional effects
- JumpCrisscross 4y ago
  > wouldn't call protein breakdown in the muscle "wasting" without additional effects Fair enough, given it's voluntary [1]. It's biologically identical to wasting, however. [1] https://en.wikipedia.org/wiki/Wasting https://en.wikipedia.org/wiki/Wasting
  - wang_li 4y ago
    There's some evidence that exercising during the fast helps minimize the loss of muscle.
    - JumpCrisscross 4y ago
      > some evidence that exercising during the fast helps minimize the loss of muscle The original point was autophagy reactivates mTOR. This isn’t a linear system. It could be that a 20-hour fast downregulates mTOR more than a 30-hour fast. (We know it works at 72 hours.)