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The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. On
by orangepurple 4y ago
The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.
- Tepix 4y ago> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.
- chrisweekly 4y agosimple != easy
- orangepurple 4y agoAgree; it was very painful initially and not easy. But very simple conceptually!
- MisterTea 4y agoI did caloric restriction for a year and eased into it gradually until I was eating two small meals a day. I had no ailments but weighed upward of 230 lbs, 104kg. In a year I went down to near zero body fat and weighed 150lbs/68kg. Unfortunately for my build and frame that made me look sickly so I started eating again and Ive settled around 165 and working to put on a little muscle. Overall I'd say I did this whole thing over two years without much effort. Though yes, getting over the hunger pangs is very hard but once over them you quickly learn to ignore them.
- cbozeman 4y agoSupplementing with potassium, magnesium, and sodium can help alleviate the hunger pangs I've found.
- bitxbitxbitcoin 4y agoI think they meant fasting.
- mrandish 4y agoTrue but after I went very low-carb, I found fasting to be much easier when it had always been very hard for me previously. I know it's more complicated than "carbs cause hunger pangs ~8 hrs later" but my N=1 experience sure feels that way.
- cbozeman 4y agoNo, there definitely seems to be a "there" there. I went zero carb for 6 months and I was able to continually fast for 24-44 hours at a time, always with zero hunger pangs after the initial "break-in" period, which seems to be about 2-3 weeks. Sadly I don't think the zero carb life is "doable" for me personally, because giving up pasta and pizza is a huge ask. Honestly I would rather die 10 years earlier than live a life with no pizza or carbonara.
- bitwize 4y agoThis is Hackernews. The cure is fasting. Whatever disease you have, the cure is fasting.
- SketchySeaBeast 4y agoAnd somehow the answer to "how did it make you healthier?" is almost always just weight loss or effects related to weight loss.
- orangepurple 4y agoJust like you wouldn't grasp the incredibility of an acid trip unless you did one yourself. Changes in one's perception of local stimuli and focus abilities are almost impossible to convey to others.
- SketchySeaBeast 4y agoIf you want to sell me on the health effects you should be able to list them. If it made you feel better but not in an objectively measurable way that's great, but that's not a health effect.
- orangepurple 4y agoMy main point was that fasting could supplement or partially replace rapamycin the drug
- SketchySeaBeast 4y agoIf that's the mechanism by which the anti-aging effect takes place that would be promising for a lot of things, because many things, including Caffeine, exercise, and traditional caloric restriction inhibits mTOR, so there's lots of options, but as the person I originally responded to pointed out, for some reason Hacker News will always choose fasting.
- arcticfox 4y ago
- chaostheory 4y agoIt’s simple, but not easy. Intermittent fasting is an easier way to start compared to traditional fasting. Imo it’s still better than other diets due to its simplicity.
- nils-m-holm 4y ago> One of the ways to inhibit mTOR for free to simply stop consuming nutrients for extended periods of time. What is an extended period of time in this context? I happen to consume all my meals within seven hours every day and only drink water in between. Would that help? (Not doing this for health reasons, it is just a habit.)
- forgotmypw17 4y agoA good measure is whether or not you feel that empty, churning feeling in your stomach. Another good measure is if you're into the idea of eating something like plain cabbage or oats.
- jtbayly 4y agoI feel that after a few hours of not eating. Is feeling it or not feeling it the sign that I've reached the necessary effect?
- funnym0nk3y 4y agoI have no personal experience with this, so I must have read I somewhere. Usually in the first hours your get hungry, which eases off after some time. After that, you can until you are hungry again.
- forgotmypw17 4y agoI think it is bare minimum for good clean digestion. As far as ALL the benefits of fasting... I think it is a good start.
- rngname22 4y agohttps://podcastnotes.org/high-intensity-health/attia-7/ https://podcastnotes.org/high-intensity-health/attia-7/ Around day 3 or day 4 of a water-only fast or (the potentially easier but still effective option of) of a fasting-mimicking diet fast.
- nik_s 4y ago
- JumpCrisscross 4y ago> ways to inhibit mTOR for free to simply stop consuming nutrients for extended periods of time How frequently and for how long must one fast to see this?
- orangepurple 4y agoAs long as you can bear it. Which for me has been 24 +/- 4 hours between meals for 9 months and counting.
- aaaaaaaaaaab 4y agoAnd what conditions did you cure with this regime? Did your overall calorie intake remain the same?
- orangepurple 4y agoBenign tumors on my skin disappeared and I lost 80 pounds
- moffkalast 4y agohttps://c.tenor.com/rI48-HMbEaMAAAAC/spaceballs-lost.gif https://c.tenor.com/rI48-HMbEaMAAAAC/spaceballs-lost.gif
- vxNsr 4y agoWhat is your current height and weight? If I were to lose 80lbs I would become emaciated.
- aidenn0 4y agoAnd if I lost 80lbs I would be on the low-side of "normal weight" by BMI.
- aaaaaaaaaaab 4y agoBenign tumors? Moles?
- CrispCas13 4y agoAs added information: metformin, a common anti-diabetic drug, is a inhibitor of mTOR. It potential adverse effects are less severe than rapamycin but are still significant. Specifically, long term usage can cause renal damage. Its mechanism of action has yet to be fully elucidated.
- deltasevennine 4y agoCan you source this? I believe you and I wanted to look into it. I googled this and I did not find anything explicitly saying renal damage. I did find many articles saying it's not safe to take if you already have renal disease but nothing saying that it causes it. I even found articles that says it doesn't cause renal failure. I'm sure what you said is some real study just not popularized yet.
- deleted 4y ago[deleted]
- wobbleblob 4y agoAges ago, I had a colleague who was deeply into hacking of his mTOR pathway. Among other things, this included a permanent calorie deficit and removal of all protein from his diet. I don't know if he's still alive. Maybe it was working a bit too well, I recall he looked like an extremely tall 13 year old with anorexia.
- LorenPechtel 4y agoYou can't synthesize some of the amino acids. I wouldn't think such a diet is survivable.
- wobbleblob 4y agoI guess the raw vegetables contain just enough protein to survive
- ShivShankaran 4y agoraw vegetables do not contain all amino acids and moreover they cannot be absorbed. You need pulses and sprouted