Yes, this. IMHO, there are two type of depression, both immune mediated, and both drive my glutamate/GABA imbalance. One is high glutamate the other is high GAB

Yes, this. IMHO, there are two type of depression, both immune mediated, and both drive my glutamate/GABA imbalance. One is high glutamate the other is high GABA, either effecting different region of the brain. This imbalance affects serotonin and norepinephrine release. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311508/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311508/ And this change is mediated by the immune system. Glutamate is now known as an immunomodulator. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997749/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997749/