4 ms·
Ketamine also has the effect of creating neuroplasticity in the 24 hours or so following administration. Even the nasal spray.
by Overtonwindow 4y ago
Ketamine also has the effect of creating neuroplasticity in the 24 hours or so following administration. Even the nasal spray.
- thatcat 4y agoSource?
- zone411 4y agohttps://pubmed.ncbi.nlm.nih.gov/31830487/ https://pubmed.ncbi.nlm.nih.gov/31830487/ "Rodent studies also demonstrate that ketamine rapidly increases BDNF and VEGF release and/or expression in the medial PFC (mPFC) and hippocampus, leading to increase in the number and function of spine synapses in the mPFC and enhancement of hippocampal neurogenesis." https://pubmed.ncbi.nlm.nih.gov/27106168/ https://pubmed.ncbi.nlm.nih.gov/27106168/ "Likewise, repeated ketamine administration increased adult hippocampal neurogenesis" https://pubmed.ncbi.nlm.nih.gov/31310776/ https://pubmed.ncbi.nlm.nih.gov/31310776/ "Our results demonstrate that a single ketamine administration promotes adult neurogenesis in the ventral hippocampus quite selectively" (mice) And a review about psychedelics in general: https://pubmed.ncbi.nlm.nih.gov/34566723/ https://pubmed.ncbi.nlm.nih.gov/34566723/ "Studies (n = 20) show that a single administration of a psychedelic produces rapid changes in plasticity mechanisms on a molecular, neuronal, synaptic, and dendritic level. The expression of plasticity-related genes and proteins, including Brain-Derived Neurotrophic Factor (BDNF), is changed after a single administration of psychedelics, resulting in changed neuroplasticity. The latter included more dendritic complexity, which outlasted the acute effects of the psychedelic. Repeated administration of a psychedelic directly stimulated neurogenesis and increased BDNF mRNA levels up to a month after treatment."