3 ms·

They should not be lumping ketamine in with all the other psychedelics which act on the serotonin 2A receptor. I’m hesitant to say ketamine is a psychedelic at

They should not be lumping ketamine in with all the other psychedelics which act on the serotonin 2A receptor. I’m hesitant to say ketamine is a psychedelic at all. Regardless, I find .25 mg of Klonopin can get rid of my depression as well, they’ve known for a long time that depression has a strong linked glutamate excitation in certain parts of the brain.

mathgladiator 4y ago
> say ketamine is a psychedelic at all. For me, whatever I experienced was definitely something. https://www.adama-platform.com/2022/07/02/the-path-of-the-monastic-code-machine.html https://www.adama-platform.com/2022/07/02/the-path-of-the-mo...
heavyset_go 4y ago
Chronic benzo administration can cause depression, so that might not work for everyone. I'd argue that the term "psychedelic dissociative" accurately captures what ketamine can be.
- FollowingTheDao 4y ago
  I do not take it chronically and no one should. I take it once, as needed. Works for a few days. And chronic ketamine use can cause depression as well: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035802/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035802/ All these drugs are not the answer. It is much more likely there is a fundamental immune dysfunction causing the depression. IMHO, all mood disorder patents should be seen by rheumatologists, not psychiatrists. https://en.wikipedia.org/wiki/Anti-NMDA_receptor_encephalitis https://en.wikipedia.org/wiki/Anti-NMDA_receptor_encephaliti... FYI: I have Sjogren's Syndrome and Discoid Lupus
krrrh 4y ago
Amongst psychedelic therapists it’s pretty normal to include Ketamine under the rubric of psychedelics these days, even though receptor purists might still object. Same is true of MDMA. From a subjective experience there’s no doubt that it’s different, but at psychedelic dose ranges most psychonauts will characterize it is a psychedelic experience, and ketamine can produce experiences every bit as weird and life altering as the tryptamines. One interesting line of research on thinking about new ways to characterize this that they all can be characterized as re-opening critical periods of development. Gul Dolen at Johns Hopkins is spearheading this, and this interview with her is worth a listen. https://www.iheart.com/podcast/1119-psychoactive-84544756/episode/gul-dolen-on-why-giving-mdma-98394543/ https://www.iheart.com/podcast/1119-psychoactive-84544756/ep...
- nibbleshifter 4y ago
  Higher (recreational) doses of ketamine can induce extremely interesting states that I would definitely classify as "psychedelic" in effect. It is an interesting drug. There are also subjectively different effects between racemic ketamine and pure S-ketamine. I have never been able to try pure R-ketamine, it just doesn't seem to be available.

mathgladiator 4y ago

> say ketamine is a psychedelic at all. For me, whatever I experienced was definitely something. https://www.adama-platform.com/2022/07/02/the-path-of-the-monastic-code-machine.html https://www.adama-platform.com/2022/07/02/the-path-of-the-mo...

heavyset_go 4y ago

Chronic benzo administration can cause depression, so that might not work for everyone. I'd argue that the term "psychedelic dissociative" accurately captures what ketamine can be.

FollowingTheDao 4y ago
I do not take it chronically and no one should. I take it once, as needed. Works for a few days. And chronic ketamine use can cause depression as well: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035802/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035802/ All these drugs are not the answer. It is much more likely there is a fundamental immune dysfunction causing the depression. IMHO, all mood disorder patents should be seen by rheumatologists, not psychiatrists. https://en.wikipedia.org/wiki/Anti-NMDA_receptor_encephalitis https://en.wikipedia.org/wiki/Anti-NMDA_receptor_encephaliti... FYI: I have Sjogren's Syndrome and Discoid Lupus

krrrh 4y ago

Amongst psychedelic therapists it’s pretty normal to include Ketamine under the rubric of psychedelics these days, even though receptor purists might still object. Same is true of MDMA. From a subjective experience there’s no doubt that it’s different, but at psychedelic dose ranges most psychonauts will characterize it is a psychedelic experience, and ketamine can produce experiences every bit as weird and life altering as the tryptamines. One interesting line of research on thinking about new ways to characterize this that they all can be characterized as re-opening critical periods of development. Gul Dolen at Johns Hopkins is spearheading this, and this interview with her is worth a listen. https://www.iheart.com/podcast/1119-psychoactive-84544756/episode/gul-dolen-on-why-giving-mdma-98394543/ https://www.iheart.com/podcast/1119-psychoactive-84544756/ep...

nibbleshifter 4y ago
Higher (recreational) doses of ketamine can induce extremely interesting states that I would definitely classify as "psychedelic" in effect. It is an interesting drug. There are also subjectively different effects between racemic ketamine and pure S-ketamine. I have never been able to try pure R-ketamine, it just doesn't seem to be available.