Isn’t it just how you handle mailboxes. Let fred@domain.com accept and receive email at any fred+X@domain.com address with ability to block any specific address

Isn’t it just how you handle mailboxes. Let fred@domain.com accept and receive email at any fred+X@domain.com address with ability to block any specific address getting spam. If the friends and family address gets spam, offer a way to create and distribute a new address. For business it is tricker as you want anyone to email you. Here regular antispam measure are probably best.