4 ms·

Or it could be something like the Hawthorne Effect where the effectiveness is because the group knew they were receiving an experimental treatment.

• SilasX 4y ago
  Yeah it seems like the closest you can do to “blinding” in this case would be to take people who haven’t been on psychedelics at all, and give the control group something that elicits a “trippy but not psychedelic experience” that is new to them, so you rule out merely “experiencing something trippy and new” like that as being the mechanism of action.
  • nibbleshifter 4y ago
    > and give the control group something that elicits a “trippy but not psychedelic experience” The doses of benadryl they were giving them as an "active placebo" are approaching levels where you do start to get some... Interesting (and often extremely distressing) deliriant effects. 0/10 would not recommend tripping on benadryl,
  • bambataa 4y ago
    There are some psychedelics (maybe 2CB, 4-Ho-Met too?) that give trippy visuals but are known for being less “in your head”. Popular with ravers because they’re easier to handle on the dance floor. It would be interesting to identify drugs that behave in this way and use them as comparators.
  • refurb 4y ago
    Studies often use amphetamine as a control. Many psychedelics have a stimulant nature to them.