That analogy of Columbus and the old world conquering due to technological superiority isn't the reason that they were able to colonize and subdue the new world

That analogy of Columbus and the old world conquering due to technological superiority isn't the reason that they were able to colonize and subdue the new world. Diseases and plagues were the reason. 90% of the native peoples where wiped out by the diseases and plagues that were inadvertently carried here. It was not a case of deliberate biological warfare but an accident that allowed for such complete colonization. Had the new world contain diseases and plagues for which old worlders had not developed resistance to or ways of dealing with then there might have been a completely different outcome. As plagues would have traveled back across the Atlantic resulting in Black plague levels of death.