I don't get why there's a comment like this in every research related thread on HN. Yes, they don't translate in the sense that "works in mice != works in huma

I don't get why there's a comment like this in every research related thread on HN. Yes, they don't translate in the sense that "works in mice != works in humans". But it's a pretty iterative and gradual process by which we make those discoveries, and the preclinical work is an important first step. A lot of applied medicine, especially recently around tumor immunology, immune checkpoint inhibitors, and such started with preclinical investigations in mice and then worked towards humans. The models certainly have limitations but they are known by the researchers and either factored into the interpretation of the studies or improved upon to create better models. (I did liver cancer research in the past, both in clincial trials and pre-clincial work where we tried therapies in mice / developed new mouse models that better replicated the tumor microenvironment for therapies).