> What if the paradigm needed isn’t remotely related to any approach that’s ever been tried? Kind of analogous to how Alzheimer drug research keeps focusing o

> What if the paradigm needed isn’t remotely related to any approach that’s ever been tried? Kind of analogous to how Alzheimer drug research keeps focusing on the amyloid plaques despite dozens if not more large clinical trials failing to prove any cognitive benefits for stuff targeting those plaques or how they form. But I guess it's easier to keep pushing for more than re-evaluating decades of work?