Have heard that many times, but in grad school it was determined orthogonally to any funded/published project, with n>3 subjects of various skin phenotypes, tha

Have heard that many times, but in grad school it was determined orthogonally to any funded/published project, with n>3 subjects of various skin phenotypes, that many super-potent small molecule compounds were not active topically in DMSO even at 100-10000x doses regardless of polarity... Read between the lines of course. Would not trust safety to that observation with any non-fun chemicals but still. Unrelatedly, microwave assisted reactions in DMSO solvent wete found to have some totally gross failure modes that were a pain to clean up and got banned in the lab