4 ms·

Here you go: https://goaskalice.columbia.edu/answered-questions/fear-teflon-flakes-found-frying-pan/ https://goaskalice.columbia.edu/answered-questions/fear-tef

• kragen 4y ago
  I really appreciate you making the effort to debunk the witch-burners; have you thought about doing it in a less ephemeral medium? Your comment will probably be here for a decade or more but nobody will read it after this month.
  • quickthrower2 4y ago
    That said people here are engaged and interested in the topic and will remember. Whereas a blogpost may not get that traction. A Netflix movie maybe.
  • blix 4y ago
    If asking for scientific research to support claims is witch-burning, truly science literacy is in a sad state. And I'm not sure I would really consider a "Go Ask Alice" column as peer-reviewed research.
    • kragen 4y ago
      But the claim in question is one of the best-known and most thoroughly established claims in all of toxicology. Asking for scientific research supporting the biocompatibility of PTFE is akin to asking for scientific research supporting biological evolution or the claim that people have landed on the moon: it's a sure sign that the person making the demand has a pre-existing flimsy pretext for rejecting literally all the research in the relevant field, which did indeed turn out to be the case; see https://news.ycombinator.com/item?id=32517203 https://news.ycombinator.com/item?id=32517203.
      • blix 4y ago
        If it's truly such a well established claim it should be trivial to find and link a study actually demonstrating its safety when ingesting small amounts over a large period of time. No such study was linked. Probably because longitudinal studies are extremely rare. It's not a rejection of all research to say that some questions remain unanswered. In fact, I'd say it is the foundation of good science to understand which claims are supported by evidence, and which claims are not.
        • kragen 4y ago
          There are half a dozen studies per year, going back decades, assessing the safety of PTFE in implants. Many of them are longitudinal. Chemists routinely boil PTFE in acids such as hydrochloric and sulfuric for hours without degrading it even slightly; such degradation would contaminate their reactions. I bet you can't find a study demonstrating natural selection in the split-leaf philodendron, either, but that isn't a good reason to go around saying "some questions remain unanswered" about whether the split-leaf philodendron is an exception to the laws of evolution.
          • blix 4y ago
            The two comment threads are the same discussion so I'm merging my responses. > I bet you can't find a study demonstrating natural selection in the split-leaf philodendron, either, but that isn't a good reason to go around saying "some questions remain unanswered" It absolutely is! The criterion for whether a question has been answered is whether that question has actually been asked, studied, and answered. In cases where there is no specific evidence, you attempt to make assumptions that extend existing evidence into spaces that it does not explicitly cover. But these aren't answers; they are educated guesses. Some guesses are better than others, and really the fundemental act of science is feeling out these hypotheses and deciding which ones are sturdy and which are shaky. So for example consider the claim 'PTFE doesn't affect human health when ingested, because there is strong evidence that is safe in implants and is chemically inert in acids.' This claim relies on two assumptions in the absence of quality direct supporting evidence: (1) Safety in one biological context directly transfers to other biological contexts and (2) Chemically inert compounds cannot affect human health. There is mounting evidence against ~both~ of these assumptions, and so claims based on them should be treated with caution, and probably as warranting further study. This is no witch-hunt, this is simply using critical thinking and available evidence to gauge the validity of assumptions, and updating the validity of claims based on changes in the validity of underlying assumptions. This process ~is~ the scientific method. > Nanometer-sized pores matter enormously, (...) but not in ways that make other forms of amorphous silica more toxic than silica gel. Try replacing your morning cheerios with silica gel and let me know the results. The pores in silica gel are specifically interesting because they allow silica to readily form hydrates. The human body has a lot of water in it. There are absolutely health effects that depend on the physical shape of silica in addition to its chemistry compared to say, consuming an equal mass of fully dense quartz particles. You'd probably have to eat a lot of silica gel to really feel the effects, but there are other more accessible and serious health concerns that are driven by nanometer or smaller physical effects. The reaction between diet coke and mentos is primarily physical, driven by nanometer-scale surface roughness on the candy. Proteins sometimes fold in abnormal shapes, and in the right circumstances, the presence of a chemically identical but differently-shaped protein can induce other proteins to change shape as well, leading to prion diseases such as Mad Cow and CJD, both of which can be acquired via ingestion of the trigger protein shapes. The claim that nanometer-sized structural changes in a compound can have no effect on human health when ingested is demonstrably false. Obviously, this calls directly into question the dependent claim that chemically inert compounds can have no possible impact on human health when ingested.
• autoexec 4y ago
  Just one. Not one of those links is a long term study on ingested PTFE coatings.
  • ars 4y ago
    And you think that ingesting PTFE is somehow worse than an actual PTFE implant? Why you insisting it must be a digestion study? Do you make such requirements for everything you interact with? Has someone done a study on using paper straws? Or plastic plates? Or metal spoons? Do you understand that when you eat PTFE it comes out exactly the same way it went in? Even powerful acids can't do anything to PTFE, what makes you think the body can do anything to it?
    • autoexec 4y ago
      > And you think that ingesting PTFE is somehow worse than an actual PTFE implant? I think that it isn't even close to being equivalent. > Why you insisting it must be a digestion study You are the one who made the statement: "It's about the most inert material that you can possibly ingest." so prove it, or admit that this is your opinion and not backed by research. I'm not even asking for research comparing the effects of the ingestion of PTFE with every other "material that you could possibly ingest", just for any data, at all, on the long term effects of ingesting PTFE. It's my understanding that the toxicity of ingested PTFE is still an open question, that there is no consensus on the safety or dangers of Teflon in food, and no research into the effects of ingesting it over/after long periods of time (say > 20 years). If you have actual knowledge of advancements in the science I'd like to see what was found, but otherwise let's just acknowledge that there is still far too much work to be done before we can make meaningful claims about the safety of ingesting PTFE. At best, what we can say right now is that it won't instantly kill you, but the long term effects of ingesting PTFE on the body are unknown.
      • ars 4y ago
        You can't have a long term study given that PTFE doesn't stay in the system, so there's nothing to study. Are you planning on feeding people PTFE every couple hours? > the long term effects of ingesting PTFE on the body are unknown. They are known. They are non-existent. You are arguing from bad faith and profound lack of knowledge of chemistry. To even hypothesize that PTFE can do anything, anything at all, to the body would require some new magical chemistry that doesn't exist. There is nothing in the body, nothing, that can affect the stability of the chemical bonds that make up PTFE - if you had even a tiny bit of scientific understanding you know that, and not embarrass yourself with these demands for studies.