The problem with NMN and NAD+ activators in general is that these don't[1] seem to increase (even) the mouse lifespan in ITP trials[2], which is more or less a

The problem with NMN and NAD+ activators in general is that these don't[1] seem to increase (even) the mouse lifespan in ITP trials[2], which is more or less a benchmark for preclinical testing of longevity-modulating substances. On the other hand, there is a handful of substances that passed this trial with evidence of some positive influence over lifespan, at least in mice, and as such are interesting candidates for human trials: [3][4][5][6]. There is also a very interesting class of substances that seem not only to extend lifespan in mice but even to rejuvenate some aspects of their physiology upon a short course of treatment: senolytics[7][8]. 1. https://www.fightaging.org/archives/2021/04/the-latest-data-from-the-interventions-testing-program-nicotinamide-riboside-has-no-effect-on-mouse-life-span/ https://www.fightaging.org/archives/2021/04/the-latest-data-... 2. https://www.nia.nih.gov/research/dab/interventions-testing-program-itp https://www.nia.nih.gov/research/dab/interventions-testing-p... 3. https://www.nature.com/articles/s41573-020-0067-7 https://www.nature.com/articles/s41573-020-0067-7 4. https://pubmed.ncbi.nlm.nih.gov/24245565/ https://pubmed.ncbi.nlm.nih.gov/24245565/ 5. https://www.nature.com/articles/nature08221 https://www.nature.com/articles/nature08221 6. https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fasebj.2018.32.1_supplement.533.112 https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/faseb... 7. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(18)30373-6/fulltext https://www.thelancet.com/journals/ebiom/article/PIIS2352-39... 8. https://www.nature.com/articles/s41591-022-01923-y https://www.nature.com/articles/s41591-022-01923-y