Personally, I am using Debian Sid. The only somewhat painful part are the proprietary Nvidia drivers when a significant kernel upgrade occurs, but it's usually

Personally, I am using Debian Sid. The only somewhat painful part are the proprietary Nvidia drivers when a significant kernel upgrade occurs, but it's usually just a matter of selecting an older kernel in grub for a few days. Other than that, it's really up to date, and with an extensive choice of packages.