4 ms·
TL;DR: new antibiotic candidate effective against gram-negative bacterias, which are generally resistant against most antibiotics because of their thick cell wa
by rex_lupi 4y ago
TL;DR: new antibiotic candidate effective against gram-negative bacterias, which are generally resistant against most antibiotics because of their thick cell walls and efflux pumps, which in combination prevents absorption of antibiotics in their cell. Favimycin shows promising results against common resistant strains of bacterias, including E.coli, further unlike other broad-spectrum antibiotics, this one doesn't affect the gut microbiome much. Current challanges include overcoming low stability in blood plasma and toxicity.
- csdvrx 4y ago> TL;DR: new antibiotic candidate effective against gram-negative bacterias, which are generally resistant against most antibiotics because of their thick cell walls and efflux pumps Aren't mycins something very well known and not novel at all? I see them listed in https://en.wikipedia.org/wiki/List_of_antibiotics https://en.wikipedia.org/wiki/List_of_antibiotics along with a link to https://en.wikipedia.org/wiki/Aminoglycoside https://en.wikipedia.org/wiki/Aminoglycoside that explain they work against gram-negative bacterias
- flobosg 4y ago“Mycin” is a suffix used in antibiotics, but does not represent a specific category anymore. If you look at the structure of fabimycin you will see that it does not resemble an aminoglycoside at all.
- John23832 4y agoThere are many bacteria that are developing resistance (or are totally resistant) to some mycins (macrolides, particularly azithromycin). Gonorrhea being a HUGE one.