There is a draft document on networking. Since only a single process may write to a database, it would be best if that process were local. NFSv4 has built-in

There is a draft document on networking. Since only a single process may write to a database, it would be best if that process were local. NFSv4 has built-in file locking, which is likely the most preferable protocol. SMBv2 is a massive rewrite of that protocol, and I expect any file locking problems would be addressed (especially as Microsoft sponsored SQLite changes specifically for Windows 10). Remote readers in explicit read-only mode likely won't hurt, but there is a deeper discussion below. https://www.sqlite.org/draft/useovernet.html https://www.sqlite.org/draft/useovernet.html