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Website to Sign Up for the Lyme Disease Vaccine Phase 3 Trial
- elektor 4y agoLiving in the Northeast, I’m tempted to enroll. Anyone know what the previous trial adverse events were?
- RichardCNormos 4y ago
- _2d30 4y ago[flagged]
- water-your-self 4y agoAn absurd response that has no place on hacker news. I recommend this video on why vaccines are significantly better than the alternatives. https://youtu.be/zBkVCpbNnkU https://youtu.be/zBkVCpbNnkU
- zzo38computer 4y agoNo vaccine is 100% safe and effective. The safety and effectiveness is presumably high enough, though, or else they would not be used (or they have found no problems yet, possibly due to the funding and the commercial interests, etc; and/or if there are some bad effects but they are rare). Also presumably they are judged as being better than the alternatives. But, that does not mean that it is 100% good, because none of them are. But still, the time that has elapsed, and tests that have been made, if shows that it is OK, then it is less cause for concern than one which has not been tested yet and might have more severe side effects.
- dr_ 4y agoFrom Pfizer’s site… but no adverse events were noted from the Phase 2 trial. https://www.pfizer.com/news/press-release/press-release-detail/valneva-and-pfizer-report-further-positive-phase-2-data https://www.pfizer.com/news/press-release/press-release-deta...
- refurb 4y agoNo. No serious vaccine-related adverse events were reported. The key word there is "serious".
- logic_beats_pro 4y agoWhy do people feel compelled to mislead others with something so important. Especially today after everything that happened with the COVID-19 vaccines. There were adverse events. There were no serious adverse events (SAEs).
- kleton 4y agoThis is presumably for VLA15, a multivalent protein subunit vaccine from Pfizer-Valneva.
- tastroder 4y agoYeah, looks like it's this one: https://clinicaltrials.gov/ct2/show/NCT05477524 https://clinicaltrials.gov/ct2/show/NCT05477524 Corresponding Phase 2 trial here: https://clinicaltrials.gov/ct2/show/NCT03769194 https://clinicaltrials.gov/ct2/show/NCT03769194
- bergenty 4y agoI can’t wait for this to be available to the general public. It’s pretty much the only thing that really concerns me when I’m out in nature.
- seibelj 4y agoI hate mosquitos. One reason I like living in the city is bug levels are severely reduced.
- deepdriver 4y agoDon't forget rabies! Or those California ground squirrels that chew through cars' brake lines.
- jupp0r 4y agoThere’s also plenty of Hanta Virus around in old cabins and mines.
- b112 4y agoOr at your house. Mice in my area have it...
- bergenty 4y agoRabies already has a vaccine.
- throwaway2037 4y agoYes, but you need to get yearly boosters. You can get it for 5 USD in Thailand (on holiday)!
- goplayoutside 4y agoSome campsites in Southern California having warning signs on their message boards about the Plague.
- throwaway_4ever 4y ago
- echelon 4y agoThis is fantastic! Every step against ticks is a good one. Now we need to find a way to prevent Lone Star ticks from making us allergic to meat. It's a big deal where I live. The ticks are not likely something we can vaccinate against, since the mechanism involves the tick priming our immune system to attack innocuous animal carbohydrates present in meat. https://en.wikipedia.org/wiki/Amblyomma_americanum https://en.wikipedia.org/wiki/Amblyomma_americanum https://en.wikipedia.org/wiki/Alpha-gal_allergy https://en.wikipedia.org/wiki/Alpha-gal_allergy
- logic_beats_pro 4y ago
- computer23 4y agoStop spreading anti-vax lies. The last lyme vaccine was safe, effective, and is still FDA approved. It certainly didn't give anyone Lyme disease. https://www.vox.com/science-and-health/2018/5/7/17314716/lyme-disease-vaccine-history-effectiveness https://www.vox.com/science-and-health/2018/5/7/17314716/lym... https://onlinelibrary.wiley.com/doi/full/10.1111/j.1468-0009.2012.00663.x https://onlinelibrary.wiley.com/doi/full/10.1111/j.1468-0009...
- logic_beats_pro 4y ago
- Technetium 4y agoI wish I could flag this.
- logic_beats_pro 4y ago
- goldenkey 4y ago
- deleted 4y ago[deleted]
- Mechanical9 4y ago> Most viral vaccines actually infect you with the virus. It is definitely not true that most vaccines infect you with the virus. Most vaccines do not use live viruses at all, and the ones that do are specifically modified to be extremely weak. This particular Lyme vaccine, VLA15, is a recombinant protein vaccine. IIUC it is basically just a particular protein that your immune system can learn to recognize and attack.
- baby 4y agoMy doctor friend tells me that it’s so uncommon that it’s not worth getting that shot.
- kube-system 4y agoIncidence rates widely vary based on where you live and what you do.
- pfdietz 4y agoIt's so common where I live that my doctor gave me prophylactic doxycycline to take whenever I have a tick bite. I took some last week.
- devwastaken 4y agoIirc you have to use the full cycle, and even that isn't guaranteed to work.
- pfdietz 4y agoThe prescription explicitly says to take just two 100mg pills upon noticing a tick bite, and then don't do that again for another week.
- Jiocus 4y agoThat's true. Here in Scandinavia it's quite common. In fact, it was only yesterday an acquaintance shared with me they are being treated for a current infection. They were in good spirits though, and health.
- michelb 4y agoIn The Netherlands ticks have become very invasive in the past few years, even in cities. I've gotten Lyme, and it certainly wasn't fun. I am happy this vaccine is on the way.
- sideshowb 4y ago
- terramars 4y agoScheduled my call with them in a week! Long overdue, but I wonder if the protein subunit still makes sense in an age where mRNA is an option. Obviously too much sunk cost to change the platform even if it was better though.
- Trouble_007 4y agoLyme Disease / Lyme Borreliosis : https://en.m.wikipedia.org/wiki/Lyme_disease https://en.m.wikipedia.org/wiki/Lyme_disease A Vaccine for Lyme Disease is in its Final Clinical Trial (August 9, 2022) : https://text.npr.org/1116500921 https://text.npr.org/1116500921
- goplayoutside 4y agoI didn't know text.npr.org was a thing. Thank you!
- Trouble_007 4y agoOT: I wish there were more text News sites. A List Of Text-Only News Sites : https://greycoder.com/a-list-of-text-only-new-sites/ https://greycoder.com/a-list-of-text-only-new-sites/
- red369 4y ago“No less arresting is Lyme disease, which comes from the bite of a tiny deer tick. If undetected, it can lie dormant in the human body for years before erupting in a positive fiesta of maladies. This is a disease for the person who wants to experience it all. The symptoms include, but are not limited to, headaches, fatigue, fever, chills, shortness of breath, dizziness, shooting pains in the extremities, cardiac irregularities, facial paralysis, muscle spasms, severe mental impairment, loss of control of body functions, and — hardly surprising, really — chronic depression.” Bill Bryson, A Walk in the Woods
- raxxorraxor 4y agoIf you post this list of symptoms on the internet it will make a lot of people believe they have Lyme disease. People that have random muscle spasm once a month might run to their doctors. Or those that found a puzzle on stackexchange and believe themselves to be mentally impaired.
- manmal 4y agoThat’s true for most symptom lists of any disease.
- LightHugger 4y agoOh... yeah, that's a very accurate description, anecdotally... Not what i expected to read on HN today. Undiagnosed lyme is really bad. I'm very happy there's a vaccine happening (again, since some awful people had the last one shut down because of fear and ignorance).
- michelb 4y agoI haven't read everything about it yet, but will this vaccine also help if you already have Lyme?
- stormdennis 4y agoI was pretty nervous about Lyme Disease a couple of years ago after there was a lot of publicity about it. Now I feel like it's all a bit overblown. I come from a family that's worked in dairy farming for generations on both sides. People who've worked in hay meadows and silage fields all their lives and there's no history at all of Lyme disease that I know of. It seems to be towns' people who occasionally visit the country side that are overwhelmingly get struck down with this which sounds to me like there's an element of hysteria about the whole thing, not least because of the number of cases where testing has proven inconclusive.
- devwastaken 4y agoIf it can be isolated and observed, it's not hysteria. Difficulty in testing and effects of the disease are not indicative of non existence.
- stormdennis 4y agoI'm not saying it doesn't exist. I know it does, it's more that it is maybe not as serious a public health issue than the coverage of it would suggest.
- radlad 4y agoFrom what I understand, both tick populations and Lyme disease cases are increasing. However, Lyme disease horror stories seem to be from people who had undiagnosed Lyme disease. My partner is currently going through medical school (M4) and believes that we are far better at detecting it today than we used to be (and she is not one to trust the medical system overall.) Of course, this is all anecdotal.
- v-erne 4y agoIt depnends on the country I suppose. Here on Poland the problem is real . I personally know two persons (my father and my cousin) who were affected by it. My father had to go to early retirement and stop being a laywer beause lyme destoyed his nervous system and he could not read longer texts anymore. My cousin almost got thrown from medical university (he could not keep up after the symptoms kicked in). Both of them did not even noticed when the tick bitten them and got through quite a long period of no symptoms. After this events I am seriously afraid of lyme - as a knowledge worker this is like a death sentence.
- bmitc 4y agoWhile great, expectations should be set. Ticks carry many diseases, including one that makes you allergic to meat and dairy.
- bjoli 4y agoWhere I live Lyme disease and TBE are the only ones you really need to worry about, and such is the case in large parts of Europe. TBE vaccines are common with a high rate of protection. A lyme disease vaccine will be very welcome.
- throwaway2037 4y agoRead more here: https://en.wikipedia.org/wiki/Alpha-gal_allergy https://en.wikipedia.org/wiki/Alpha-gal_allergy Any insect that sucks your blood falls into the same terrible category: tse tse fly, mosquito, kissing bugs.
- scrappyjoe 4y agoThey plug straight into your blood stream without any sort of intermediate filter mechanisms. Kinda like the USB port of parasitic strategies…
- deleted 4y ago[deleted]
- molszanski 4y agoFingers crossed
- dharma1 4y agoGreat news. My 7yo son just got a tick bite while on holiday in Finland, with the tell tale bullseye ring around it appearing in a few days around the itchy bite area. We never saw the tick, would have missed it if not for the skin symptoms. Fortunately early course of antibiotics has an extremely good success rate against the bacteria - but if it’s undetected it’s much less effective when you get more serious symptoms months later. Ticks spreading borreliosis are a very common in Northern Europe, you can protect yourself with clothing and thorough check every time you’ve been in long grass or forested areas - but some bites still go unnoticed, this vaccine is fantastic news
- bjoli 4y agoi got the same thing, but without the ring. When I got antibiotics it had already started affecting my nervous system. I had to eat antibiotics for 3 months. Despite having Lyme disease I am not protected. If a vaccine comes In will take it without hesitation.
- bsaul 4y agoStrangely, i know someone from lithuania that told me her whole family got vaccinated against lyme. Does a working vaccine already exists ?
- locallost 4y agoThere is none. There are other diseases you can get from ticks, such as encephalitis, and there is a vaccine for it, so maybe the friend mixed the two up.
- DennisP 4y agoOr they got the Lyme vaccine a couple decades ago. > In 1998, the FDA approved a new recombinant Lyme vaccine, LYMErix™, which reduced new infections in vaccinated adults by nearly 80%. Just 3 years later, the manufacturer voluntarily withdrew its product from the market amidst media coverage, fears of vaccine side-effects, and declining sales. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/
- headsoup 4y ago> and declining sales The real reason
- dudeDDRrulez 4y ago>fears of vaccine side-effects Actual vaccine side effects and law suits. They settled for millions.
- DennisP 4y agoThere were lawsuits and they found it safest to settle, but that doesn't mean the complaints had statistical validity. According to the paper I posted, the FDA found no evidence of the vaccine causing harm. Even if harm had occurred, it would have to be weighed against the risk of harm from Lyme disease.
- mauvehaus 4y agoUnrelated to the trial but their UX is a little weak: their signup page at least starts with finding a nearby location. If you start with putting in a ZIP code, it populates the drop down with possible autocompletes. Then when you choose one out of range of a site, you get the error "That address can't be located. Please try again." That rather suggests an address entry error, not (what I can only infer) is a lack of nearby study sites error. If you're not near a site for this study, you might also try the Valor study: https://www.valorlymestudy.com/ https://www.valorlymestudy.com/ I am not a doctor, and I cannot speak to the relative merits of one over the other. I'm also too far from either to participate :-/
- spywaregorilla 4y agoThe number of people commenting on how common lyme disease is based on local anecdotes without acknowledging it's an insect borne disease and going to vary wildly by geography is silly.
- dudeDDRrulez 4y agoHere we go again… yes I want my debilitating arthritis to come from the vaccine instead of the actual infection like what happened with Lymerix. Eye roll
- rrrrrrrrrrrryan 4y agoThe story of Lymerix is a sad one. People want vaccines to have zero side effects, zero risks, and be applicable to the entire population. With Lymerix, the upsides of the vaccine vastly outweighed the downsides for people who live in areas with Lyme-carrying ticks, (especially those who spend significant time outdoors), but for most of the population it was pure downsides. It's a damn shame that antivaxers were about to get it taken off the market entirely because it would have helped a lot of people.
- dudeDDRrulez 4y agoThe same “antivaxers” that elected to take the Lymerix vaccine, were injured and then fought to stop others from also being injured? The profoundly idiotic weaponized use of the word antivaxer will be an embarrassment for decades to come. “Damn antivaxers!” “But they have all their recommended vaccinations and only were injured with myocarditis on their second COVID Booster”. “…damn antivaxers!”
- rrrrrrrrrrrryan 4y ago> But they have all their recommended vaccinations and only were injured with myocarditis on their second COVID Booster. If these people got COVID boosters taken away from everyone, I would absolutely say "damn antivaxers." A COVID booster has legitimate risks and doesn't make sense for everyone. Any Lyme vaccine will be similar. But they absolutely make sense for some people, and people should be able to make the choice with their doctor to get one.
- origin_path 4y agoVery sensible. If everyone had adopted that viewpoint then there'd be far fewer "antivaxxers" in the world. Vaccines as pure commercial products you buy for your own use, with governments getting out of the way as much as possible, would be far less controversial. Unfortunately governments can't stay away from the idea of forcing everyone to vaccinate in reach herd immunity, a concept that seems to appear and disappear depending on what public health wants you to do today. How many people have to take it to reach this threshold? Nobody knows because the people who are supposed to know what it is make it up in order to generate compliance (Fauci admitted to doing this in the New York Times). For people to start trusting vaccines again, they need to be treated like any other drug. The idea of policy-created herd immunity is attractive but too destructive to tolerate. Once governments think they have a magic policy solution to a problem they can't resist pushing it regardless of consequences.
- logic_beats_pro 4y agoDoes it do anything against Babesia, Anaplasma, Bartonella, Erlichia, Epstein Barr Virus, HHV-6, Mycoplasma Fermentans, Mycoplasma pneumoniae, Chlamidia trachomatis, Yersinia enterocolitica or any of the other known Lyme coinfections?