From the CDC page: > “The mRNA and the spike protein do not last long in the body. > Our cells break down mRNA from these vaccines and get rid of it within a

From the CDC page: > “The mRNA and the spike protein do not last long in the body. > Our cells break down mRNA from these vaccines and get rid of it within a few days after vaccination. The paper “Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination”, Röltgen et al. 2022, published in the journal Cell: > “Prolonged detection of vaccine mRNA in LN GCs and spike antigen in LN GCs and blood following SARS-CoV-2 mRNA vaccination > The biodistribution, quantity, and persistence of vaccine mRNA and spike antigen after vaccination and viral antigens after SARS-CoV-2 infection are incompletely understood but are likely to be major determinants of immune responses. > We performed in situ hybridization with control and SARS-CoV-2 vaccine mRNA-specific RNAScope probes in the core needle biopsies of the ipsilateral axillary LNs that were collected 7–60 days after the second dose of mRNA-1273 or BNT162b2 vaccination and detected vaccine mRNA collected in the GCs of LNs on days 7, 16, and 37 postvaccination, with lower but still appreciable specific signal at day 60 (Figures 7A–7E).” > https://www.cell.com/cell/fulltext/S0092-8674(22)00076-9#sec2.7 https://www.cell.com/cell/fulltext/S0092-8674(22)00076-9#sec... Maybe I’m reading it wrong, but I understand this as saying that the modified mRNA (using pseudouridine) does not degrade nearly as fast as normal mRNA, “Our cells break down mRNA [...] within a few days” vs. 60 days or more. Now, this is not my area of expertise and I can’t say whether that’s important or not.