4 ms·

So what are the ways to lower glumate buildup?

• synaesthesisx 4y ago
  Glutamate is the primary excitatory neurotransmitter, and GABA is the primary inhibitory neurotransmitter. They’re supposed to keep each other in balance (to an extent), so increasing GABA should theoretically lower glutamate. Perhaps that drink after work isn’t such a bad idea after all…
  • spoonjim 4y ago
    Huh. A biochemical model of the Ballmer Peak.
  • bregma 4y ago
    Mmmm, balancing the humors. Back to the good old days.
• paraiuspau 4y ago
  I’ve had great success with N-Acetyl Cysteine (NAC) which brings glutamate back into balance with GABA [1]. The upshot of this is, it’s reduced my binge-like behaviours massively, although I’m slightly more anhedonic than before.. or maybe just balanced now. Also clears the chest very rapidly. YMMV. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182588/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182588/
  • samloveshummus 4y ago
    Good for you, but NAC has a host of effects so you couldn't say it was due to glutamate for sure. For example, NAC mainly increases glutathione, the primary antioxidant your body uses, so it may reduce the level of oxidative stress and lower your body's stress response. It also increases the level of SAM-e in your body (as you can transform sulfur containing amino acids methionine and cysteine into each other). SAM-e is a crucial cofactor for many processes including creation of neurotransmitters such as dopamine and serotonin. And an increase in sulfur amino acids (including NAC) also modulates your gut microbiome.
    • paraiuspau 4y ago
      Great additional info - I will look into these things in more depth, thank you.
• markdown 4y ago
  Drink kava. https://kavaforums.com/forum/threads/kavain-and-glutamate.18689/ https://kavaforums.com/forum/threads/kavain-and-glutamate.18...
• macrolime 4y ago
  Sleep. In the daytime, maybe a powernap or 15 minutes of mediation could work.