Are there any known examples where evolution has produced a solution to a problem like this? I've heard of humans adapting to Malaria and lactose consumption in

Are there any known examples where evolution has produced a solution to a problem like this? I've heard of humans adapting to Malaria and lactose consumption in adulthood. Also, are there any organisms that don't experience lead as a toxic substance, at least in the way that humans do? That might point to adaptation plausibility.