> Is it useful for rational vaccine design Not really. Vaccines -> antibodies produced from some of the cells modeled. This might help with adjuvants to vacc

> Is it useful for rational vaccine design Not really. Vaccines -> antibodies produced from some of the cells modeled. This might help with adjuvants to vaccines (which are co-administered with vaccines to increase effectiveness by ramping up the immune system). Vaccine design now is pretty "rational" (well-understood): Find an immunogenic stable and accessible epitope on the pathogen, and replicate that in the vaccine. It's the *production* of vaccines that's hard. COVID vaccine design was tricky because the key/unique epitope is hidden by a conformational change until cell entry, but still that was basically solved in a year. The magic lies in the new mechanism for producing the immunogenic epitope: by supplying RNA templates to your own cells to produce the protein. The hard design/modeling problem is auto-immunity, in all its forms.