4 ms·
I work in human diabetes genetics. We're just publishing work on a gene that doesn't even exist in mice - https://www.medrxiv.org/content/10.1101/2021.08.23.212
by mnw21cam 4y ago
I work in human diabetes genetics. We're just publishing work on a gene that doesn't even exist in mice - https://www.medrxiv.org/content/10.1101/2021.08.23.21262262v1 https://www.medrxiv.org/content/10.1101/2021.08.23.21262262v...
Part of our message is basically what you just said. We have multiple examples of genes where mutations cause diabetes in humans but don't in mice.
The other one we have is the fact that human pancreatic beta cell lines in labs don't even 100% act like human pancreatic beta cells in humans.