I tend to use with a meaning more nuanced towards "boring". What's going to happen is so extremely boring, that I'd better be sedated, high on drugs or the like

I tend to use with a meaning more nuanced towards "boring". What's going to happen is so extremely boring, that I'd better be sedated, high on drugs or the like in order to withstand it. I can see how the "drug" thing might shift the meaning to be: you must be high on drugs in order to suggest something this arduous.