4 ms·
A model system that’s expendable (meaning you can repeat experiments in hundreds or thousands), cheap, and perfectly represents a human organ and also its immun
by ramraj07 4y ago
A model system that’s expendable (meaning you can repeat experiments in hundreds or thousands), cheap, and perfectly represents a human organ and also its immune system. Currently mice are used. But mice aren’t human! This didn’t matter too much when the drugs were simple and affected proteins that don’t change much in mammals but now we’re generally worried about diseases very specific to humans. Do you know we have many types of humanized mice? There are now very successful organoids research teams making great progress. These are far more exciting for drug discovery than getting the whole proteome structure catalogued. But that doesn’t involve computers so it’s not as exciting for a large population of technical people who want to help.
Unless of course you think you can truly model the entire human body pharmacologically using AI or whatever. That’ll help.
https://www.jax.org/news-and-insights/jax-blog/2020/july/why-humanized-mice https://www.jax.org/news-and-insights/jax-blog/2020/july/why...