I think Alphafold will be of immense value. The article is too pessimistic. Alphafold will reveal a huge number of structural parameters that can be exploited

I think Alphafold will be of immense value. The article is too pessimistic. Alphafold will reveal a huge number of structural parameters that can be exploited by careful synthetic chemistry. You can know what base pair to change and see if that changes or blocks function. Things like Paxlovid can be tweaked towards an optimum. It is an analog to the way the Rosetta stock unlocked a few ancient languages. With this tool a huge number of testable structures will be amenable to tweaking, since we now have online ordering of almost any sequence. The tedious step will be the wet testing, but that has been solved by the multiple well test slides.We can now sequence and protein via dye/pore/emf methods. https://en.wikipedia.org/wiki/Nanopore_sequencing https://en.wikipedia.org/wiki/Nanopore_sequencing