The crystallographically-determined structures are the ground truth! [1] Saying that AlphaFold makes x-ray crystallography useless is like saying DALL-E makes

The crystallographically-determined structures are the ground truth! [1] Saying that AlphaFold makes x-ray crystallography useless is like saying DALL-E makes photography useless or Copilot makes GitHub useless. You've got the dependency chain backwards. [1] (Or at least, they're treated as the ground truth---they don't necessarily predict the conformation of proteins in solution, but that's a separate topic for another thread).