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Alphafold demonstrated beyond any reasonable doubt that crystallography by itself is useless in certain circumstances. There are plenty of research groups worki
by tigershark 4y ago
Alphafold demonstrated beyond any reasonable doubt that crystallography by itself is useless in certain circumstances.
There are plenty of research groups working on crystallography that found the correct solution only combining their data with Alphafold data.
In the last competition, if I remember correctly, there was one protein that escaped crystallography for many years until they used Alphafold predicted structure.
I’m not really sure how can you simply discount these really groundbreaking results when crystallography provided much less wins in many more years.
- l33tman 4y agoYou are aware of that almost all known protein structures come from crystallography?
- pas 4y agoHow much of the AlphaFold training data is from crystallography results?
- evouga 4y agoThe crystallographically-determined structures are the ground truth! [1] Saying that AlphaFold makes x-ray crystallography useless is like saying DALL-E makes photography useless or Copilot makes GitHub useless. You've got the dependency chain backwards. [1] (Or at least, they're treated as the ground truth---they don't necessarily predict the conformation of proteins in solution, but that's a separate topic for another thread).