Note: the 2021 preprint version https://www.biorxiv.org/content/10.1101/2021.11.30.470657v1.full https://www.biorxiv.org/content/10.1101/2021.11.30.470657v1....

Note: the 2021 preprint version https://www.biorxiv.org/content/10.1101/2021.11.30.470657v1.full https://www.biorxiv.org/content/10.1101/2021.11.30.470657v1.... was also extensively discussed, so that is why this might sound familiar.