7 ms·
(It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose.) Anecdotally, I've ha
by yarg 4y ago
(It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose.)
Anecdotally, I've had a degree of short term success treating my depression with smallish doses of mushrooms, but I've never had the continuing access required for a microdosing regiment.
It'd be nice if the government were willing to come to the table on this, but alas.
That said, every time that I've had a months long lift, it hasn't been a small dose, but an epic dose that often cast me into a night of turmoil.
(Which would make the rigours of double-blind testing completely ineffectual.)
- timthorn 4y ago> It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose. Not really - its from the Greek for small, rather than a SI prefix in this context. If the suffix were quantitative then you might have a case, but we talk quite happily about microphones and microscopes. Microdose is useful because it is not conditional on a particular regular dose size, we just know it is much lower than usual.
- quickthrower2 4y agoWhat is the difference between "Low Dose" and "Microdose" though? I have heard the specific term Low Dose before.
- carrychains 4y agoGenerally, a microdose is supposed to be below threshold. In other words, imperceptible. A low dose can be above threshold. This study seems to be testing something most microdose adherents would refer to as a low dose.
- eurasiantiger 4y agoMicrodose = sub-perceptual dose Threshold dose = dose at which effects can barely be perceived Low dose = dose at which effects become definitely perceptible The people in this study were taking something between a threshold dose and a low dose, given some interpersonal variability.
- carrychains 4y ago.5 is definitely a low dose for anyone who has experienced it more than a few times or an actual low dose at least once. Realistically, I'd expect only a first timer could possibly think .5 is imperceptible.
- deleted 4y ago[deleted]
- comonoid 4y agoAlso, 1 microbe is 1/1000000 of be.
- richthegeek 4y agoMicrobes are actually around 1 micrometer! Whilst I'd generally hate for a 1 meter bee to exist, it might be worth it just for the nerd joke. So purely factually, a microbe is only 1/10000th of a bee
- bch 4y ago> Whilst I'd generally hate for a 1 meter bee to exist Luckily for you a rare sight - https://upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Samsung_SyncMaster_191T_and_BeBox_20081114.jpg/800px-Samsung_SyncMaster_191T_and_BeBox_20081114.jpg https://upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Sa...
- adrian_b 4y agoWhile "micro" means indeed small, many people have the wrong impression that the similarly sounding "macro" must have an opposite meaning to "micro" so many incorrect terms have been coined, e.g. "macroscopic" vs. "microscopic". In reality, in Ancient Greek the opposite of "micro" was "mega", i.e. "big" (so megameter vs. micrometer was a correct addition to the metric system in 1873, like also the name Micromegas, which was coined by Voltaire in one of his novellas), while "macro" meant "long", not "big". ("macro" is cognate with words from other European languages which mean slim/slender/thin/lean, only in Ancient Greek its meaning has shifted from "slim" to "long", replacing the older word for "long", "dolicho").
- jimmaswell 4y agohttps://www.merriam-webster.com/dictionary/macro https://www.merriam-webster.com/dictionary/macro
- adrian_b 4y agoThat dictionary only records the fact that most English speakers now use the word "macro" incorrectly, which was my point, because they do not know Ancient Greek and they follow some previous English speakers who also did not know Ancient Greek, but that did not stop them to use a Greek word they thought as sounding fancy and whose meaning they attempted to guess, without bothering to look in a dictionary, so they have guessed wrong. This incorrect use of "macro" in English appears to have started in the second half of the 19th century, when the study of the classical languages in school was already in regression.
- detaro 4y agoThe dictionary records what word means, today, in the english language.
- adrian_b 4y agoLike everybody else, I also have to use the words with their current meaning, so I use frequently words like "macroinstruction", possibly abbreviated to "macro", or "macroprocessor". That does not mean that one should not be aware that the creation of such words was based on laziness and ignorance and one should not coin any new words of this series.
- mritchie712 4y agoHave you tried Kratom? I'm by no means recommending it, just curious if you've tried it to combat depression.
- BossingAround 4y agoAs a daily Kratom user, I would not recommend using Kratom for something like depression. You're treating the symptomps at best while cultivating addiction.
- helsinki 4y agoYeah, always best to not fuck around with chemicals that bind to gabba receptors (alcohol, benzodiazepine, kratom). It will give you a hell of a withdrawal if you take high doses. This is why there are alcoholics.
- irthomasthomas 4y agoWhere did you read that kratom binds to gaba? I haven't heard that.
- BossingAround 4y agoKratom binds primarily to mu-opioid receptors. It's a bit disingenuous to say it binds to gabba. I mean, I am sure it is true that some alkaloids in Kratom bind to gabba, but that's not the primary interaction.
- loeg 4y agoWhy daily?
- BossingAround 4y agoChronic pains. I try to skip days when my pain is better, but those are not very frequent.
- 4y ago
- hackerlight 4y ago> night of turmoil. Can you elaborate?
- jmartrican 4y agoMy guess is OP is referring to a bad (or powerful) trip.
- InCityDreams 4y agoWhereas I'd say 'turmoil', is a beautifully-concise word to describe great trips, too.
- yarg 4y agoHanging out with spider demons at the end of time, that sort of shit.
- kebman 4y agoWhy do you want to change your condition with a thing, when the answer is inside you?
- game-of-throws 4y agoI think decidose would be even less accurate. A normal dose is 3g-5g. A microdose is 0.1g-0.2g. That's not a ratio of 10. At least microdose has a widely-agreed on colloquial meaning.
- yarg 4y ago> We investigated the acute and short-term effects of 0.5 g of dried mushrooms on subjective experience, behavior ... and brain activity.
- 34679 4y agoI'm of the belief that it should be called a dose. There are many therapeutics that will make you hallucinate if you ingest too much. We call that an overdose.
- dylan604 4y agoWhile others might call that the point.
- jrochkind1 4y ago> It'd be nice if the government were willing to come to the table on this, but alas. They're starting to, although they haven't funded a study on microdosing for depression. > [October 2021] Johns Hopkins Medicine was awarded a grant from the National Institutes of Health (NIH) to explore the potential impacts of psilocybin on tobacco addiction. This is the first NIH grant awarded in over a half century to directly investigate the therapeutic effects of a classic psychedelic https://www.hopkinsmedicine.org/news/newsroom/news-releases/johns-hopkins-medicine-receives-first-federal-grant-for-psychedelic-treatment-research-in-50-years https://www.hopkinsmedicine.org/news/newsroom/news-releases/...
- yarg 4y agoDifferent country, even more useless government. Though the progress in the US/Canada makes me think that maybe in 15-20 years NZ can have a referendum and continue with prohibition.