I think if you don't use some relatively niche packages, nix is fine. However there are some quirks such as setting LD_LIBRARY_PATH for CUDA that may need some

I think if you don't use some relatively niche packages, nix is fine. However there are some quirks such as setting LD_LIBRARY_PATH for CUDA that may need some tinkering. If you want to give nix another try, I strongly recommend you to use nix flakes and home manager. Nix flakes allows you to pin dependency versions, and home manager provides a lot of configurations for commonly used packages.