Yeah, any study that says something like "This specific SSRI doesn't work for some people, works massively well for others, therefore it's not an effective trea

Yeah, any study that says something like "This specific SSRI doesn't work for some people, works massively well for others, therefore it's not an effective treatment" should really be tossed in the bin. It's funny that you mention Tylenol as an example, as acetaminophen/paracetamol is the only over-the-counter pain killer that works for me. Ibuprofen does literally nothing for me and I've had to convince my doctors to list it as an "allergy" on my medical records just so my health care providers will stop suggesting it. But that doesn't mean ibuprofen is not effective for other people. I was prescribed SSRIs for a while, back in a particular bad part of my life (financial stress, job I hated, lots of health problems with everyone in my family). If we're going to say that all SSRIs are basically placebo, then I was not in any mental mood to believe that anything a doctor would prescribe to me would be effective. And in my case, Wellbutrin was not. In fact, it had a very significant deleterious effect in that it made me a raging asshole. But Lexapro, on the other hand... night and day difference. (Thankfully, job changed, everyone's health got better, and now I'm no longer on anything other than blood pressure and cholesterol meds, which, come to think of it, is round-about treating the knock-on effects of my years of untreated depression). Placebo effect is never a large effect. If you see a large effect, it's pretty safe to say it's not placebo.