Most people I've met who use ketamine at all are addicted to ketamine, and long-term heavy usage has severe negative consequences. It has therapeutic uses and

Most people I've met who use ketamine at all are addicted to ketamine, and long-term heavy usage has severe negative consequences. It has therapeutic uses and can be used to treat otherwise untreatable depression, but the risks are severe if somebody seeks it out on their own. MDMA is a good trip, but damn the hangover: I wouldn't suggest your friend endure "suicide Tuesday." Shrooms and LSD can be effective, but a bad trip can aggravate depression and anxiety. There are no silver bullets. Therapeutic uses involve therapists. The only advice I can give is that your friend seek out a competent therapist.